Jonas Michel Wolf

Dengue Virus in the 21st Century: Transmission, Pathogenesis, and Climate-Driven Challenges

Rafaela Munari da Silva, Juliana Haider Neves, Pamela Fagundes Wolf, ANA CLARA MICHEL WOLF et autres

Dengue virus (DENV) remains a major global public health challenge, driven by the expanding distribution of Aedes vectors, rapid urbanization, and increasing climate variability. This review aimed to synthesize current evidence on dengue transmission dynamics, immunopathogenesis, molecular epidemiology, diagnostic and therapeutic advances, …

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The role of health institutions in the epidemiological surveillance of arboviral diseases in Rio Grande do Sul, Brazil: notification, hospitalization, and regional differences

Lucas Felipe Kist, Jonas Michel Wolf, Maike Luan Gomes Rocha, Amauri Duarte da Silva et autres

BACKGROUND: Arboviral diseases represent a growing public health challenge worldwide, with Brazil reporting the highest number of dengue cases and recent expansion into southern regions. Effective epidemiological surveillance relies on the capacity of health institutions to identify, notify, and manage cases. This …

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Terapia Médica Direcionada por Diretrizes, Desfechos Clínicos e Qualidade de Vida na Insuficiência Cardíaca: Insights de uma Coorte Brasileira Multicêntrica Baseada no International Consortium for Health Outcomes Measurement

Suzana Alves da Silva, Keila Amaral, Sabrina Bernardez‐Pereira, Daisa de Mesquita Escobosa et autres

Resumo Fundamento Evidências de mundo real que integrem desfechos clínicos e medidas relatadas pelos pacientes na insuficiência cardíaca com fração de ejeção reduzida (ICFEr) ainda permanecem escassas em países de renda média. Estruturas padronizadas para mensuração de desfechos podem permitir uma avaliação …

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Association Between Inflammatory Markers, Comorbidities, and Mortality in COVID‐19 Patients Treated With Tocilizumab

Rafaela Munari da Silva, Melissa K. Soper, Juliana Haider Neves, Carlos Emanuel Antunes Maciel et autres

Tocilizumab, an interleukin-6 receptor antagonist, has been widely used in the management of severe COVID-19 cases, but its clinical outcomes have been variable. A retrospective cohort including 113 hospitalized adult patients with confirmed COVID-19 treated with tocilizumab between March and October 2021 …

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Transforming Care through Outcomes Measurement: Experience in a Southern Brazilian Hospital

Jonas Michel Wolf, Arthur Pille, Lucas Felipe Kist, Helena Petek et autres

BACKGROUND: Standardized outcome measurement is a core component of value-based healthcare, yet real-world evidence on long-term system-wide implementation remains limited. OBJECTIVES: To evaluate the longitudinal clinical and patient-reported outcome impact of implementing condition-specific, outcome-driven care pathways across multiple specialties. METHODS: Between 2017 …

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Longitudinal Assessment of Functional Outcomes in Post‐Prostatectomy Patients: Analysis of Urinary, Intestinal, Sexual and Hormonal Functions in a Private Hospital in Southern Brazil

Jonas Michel Wolf, Arthur Pille, Lucas Felipe Kist, Rafaela Munari da Silva et autres

ABSTRACT To evaluate urinary, intestinal, sexual and hormonal functions using validated Patient‐Reported Outcome Measures (PROMs) for the Brazilian population in prostate cancer patients. This prospective observational study longitudinally assessed the functional outcomes of 800 patients who underwent prostatectomy at a private hospital …

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Improvements in Timely Care and Patient-Reported Outcomes for Breast Cancer: A Seven-Year Southern Brazilian Cohort Analysis

Rafaela Munari da Silva, Melissa K. Soper, Larissa Conrado Martins, Isadora Ramos de Sousa et autres

Background/Objective: Breast cancer is one of the leading diseases affecting the Brazilian population and is often diagnosed at advanced stages. Due to its heterogeneity, treatment involves multiple therapeutic modalities, such as chemotherapy, hormone therapy, immunotherapy, and radiotherapy. The aim of this study …

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Age distribution of respiratory syncytial virus disease in children younger than 5 years in low-income and middle-income countries: a systematic review and meta-analysis

Sarwat Mahmud, Kevin van Zandvoort, Ling Guo, You Li et autres

BACKGROUND: Low-income and middle-income countries (LMICs) bear the greatest burden of respiratory syncytial virus (RSV) disease. WHO recommends passive immunisation to protect infants younger than 6 months and, in some strategies, infants up to age 12 months, but detailed age data are …

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Guideline-Directed Medical Therapy, Clinical Outcomes, and Quality of Life in Heart Failure: Insights from a Multicenter International Consortium for Health Outcomes Measurement-Based Brazilian Cohort

Suzana Alves da Silva, Keila Amaral, Sabrina Bernardez‐Pereira, Marcelo Franken et autres

Background Real-world evidence integrating clinical outcomes and patient-reported measures in heart failure with reduced ejection fraction (HFrEF) remains scarce in middle-income countries. Standardized outcome measurement frameworks may enable more consistent evaluation of care quality and treatment effectiveness. Objective To assess the association …

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AUTOPERCEPÇÃO DA APARÊNCIA NO CENÁRIO CONTEMPORÂNEO: ENVELHECIMENTO E A BUSCA POR PROCEDIMENTOS ESTÉTICOS REJUVENESCEDORES

DAIANE POPP FLORES, Jonas Michel Wolf, Mauricio Sprenger Bassuino

O ENVELHECIMENTO CELULAR COMO ELO ENTRE IDADE MATERNA AVANÇADA E COMPLICAÇÕES NA GESTAÇÃO: UMA REVISÃO INTEGRATIVA DA LITERATURA

HINGRID ALMEIDA STORCH, Felipe dos Santos Moysés, Felipe Borges Almeida, Jonas Michel Wolf

EVOLUÇÃO TEMPORAL DO TEMPO PARA TRATAMENTO E DOS DESFECHOS RELATADOS POR PACIENTES COM CÂNCER DE MAMA: COORTE LONGITUDINAL DE SETE ANOS

HINGRID ALMEIDA STORCH, DAIANE POPP FLORES, Juliana Haider Neves, Jonas Michel Wolf et autres