Paolo De Giuli

Patient and Context Factors in the Adoption of Active Surveillance for Low-Risk Prostate Cancer

Giovannino Ciccone, Stefano De Luca, Marco Oderda, F. Muñoz et autres

Importance: Although active surveillance for patients with low-risk prostate cancer (LRPC) has been recommended for years, its adoption at the population level is often limited. Objective: To make active surveillance available for patients with LRPC using a research framework and to compare …

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From Academy to Stage

Paolo De Giuli

Blockade of Thrombopoietin Reduces Organ Damage in Experimental Endotoxemia and Polymicrobial Sepsis

Alessandra Cuccurullo, Elisabetta Greco, Enrico Lupia, Paolo De Giuli et autres

BACKGROUND AND PURPOSE: Thrombopoietin (TPO), a growth factor primarily involved in thrombopoiesis may also have a role in the pathophysiology of sepsis. In patients with sepsis, indeed, TPO levels are markedly increased, with disease severity being the major independent determinant of TPO …

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Detection and characterization of classical and “uncommon” exon 19 Epidermal Growth Factor Receptor mutations in lung cancer by pyrosequencing

Luisella Righi, Alessandra Cuccurullo, Simona Vatrano, Susanna Cappia et autres

BACKGROUND: The management of advanced stage non-small cell lung cancer is increasingly based on diagnostic and predictive analyses performed mostly on limited amounts of tumor tissue. The evaluation of Epidermal Growth Factor Receptor (EGFR) mutations have emerged as the strongest predictor of …

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Tumor Staging But Not Grading Is Associated With Adverse Clinical Outcome in Neuroendocrine Tumors of the Appendix

Marco Volante, Lorenzo Daniele, Sofia Asioli, Paola Cassoni et autres

Appendiceal neuroendocrine neoplasms (NENs) are rare and usually incidentally discovered. Most cases are clinically indolent, although the rare aggressive ones are poorly predictable. The aim of this study was to test the applicability and prognostic significance of the new World Health Organization …

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Involvement of thrombopoietin in the development of organ injury in a mouse model of cecal ligation and puncture-induced sepsis

Elisabetta Greco, A Cuccurullo, Barbara Laface, Daniela Gallo et autres

Sepsis-induced organ damage is a leading cause of death in critically ill patients. Thrombopoietin (TPO) is a humoral growth factor mainly involved in regulation of platelet number and function. High circulating levels of TPO are detectable in septic adults and children and …

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Selective Inhibition of Carbonic Anhydrase IX Decreases Cell Proliferation and Induces Ceramide-Mediated Apoptosis in Human Cancer Cells

Fabio Cianchi, Maria Cristina Vinci, Claudiu T. Supuran, Benedetta Peruzzi et autres

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INTRA-OPERATIVE PATHOLOGICAL STAGING OF PROSTATE CANCER DURING RADICAL RETROPUBIC PROSTATECTOMY

Sergio Lacquaniti, Paolo De Giuli, Pier Paolo Fasolo, E. Conti et autres

Lack of phosphoinositide 3-kinase-γ attenuates ventilator-induced lung injury*

Vincenzo Lionetti, Alberto Lisi, Enrico Patrucco, Paolo De Giuli et autres

OBJECTIVE: G protein-coupled receptors may up-regulate the inflammatory response elicited by ventilator-induced lung injury but also regulate cell survival via protein kinase B (Akt) and extracellular signal regulated kinases 1/2 (ERK1/2). The G protein-sensitive phosphoinositide-3-kinase gamma (PI3Kgamma) regulates several cellular functions including …

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Skewing Towards Neuroendocrine Phenotype in High Grade or High Stage Androgen-Responsive Primary Prostate Cancer

Luca Puccetti, Claudiu T. Supuran, Pier Paolo Fasolo, E. Conti et autres

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Ablation of Phosphoinositide 3-Kinase-γ Reduces the Severity of Acute Pancreatitis

Enrico Lupia, Alberto Goffi, Paolo De Giuli, Ornella Azzolino et autres

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Epidermal growth factor receptor overexpression correlates with a poor prognosis in completely resected non-small-cell lung cancer

Giovanni Selvaggi, Silvia Novello, Valter Torri, E Leonardo et autres

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