Phillip M. Mackie

C1q-dependent clearance of alpha-synuclein allows macrophages to transiently limit enteric synucleinopathy in male mice

Phillip M. Mackie, Joanne M. Koshy, M Bhogade, T Hammoor et autres

Deposition of misfolded α-synuclein (αsyn) in the enteric nervous system (ENS) is found in multiple neurodegenerative diseases. It is hypothesized that ENS synucleinopathy contributes to both the pathogenesis and non-motor morbidity in Parkinson’s Disease (PD), but the cellular and molecular mechanisms that …

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Quality improvement approach to reduce patient cycle time at a student-run free healthcare clinical network

René Kronlage, Amy Stanley, Miranda J. Reid, William Hudson Shaw et autres

BACKGROUND: The University of Florida (UF) Equal Access Clinic Network (EACN) is the largest student-run free healthcare clinic network in Florida. The UF EACN serves those who are underinsured or uninsured in Alachua County and its surrounding area. Nationally, average total clinic …

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Providing Prenatal Care in a Student Run Free Clinic

Chloe Warpinski, Nathan Burke, Sanaz Dovell, Michelle C. McCraw et autres

Background: Prenatal care is a cornerstone of maternal and child health. This paper describes the creation of a free prenatal clinic for uninsured families following recognition of a significant disparity in birth outcomes in Alachua County, Florida including: the development of essential …

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Complement C1q-dependent engulfment of alpha-synuclein induces ENS-resident macrophage exhaustion and accelerates Parkinson’s-like gut pathology

Phillip M. Mackie, J Koshy, M Bhogade, T Hammoor et autres

Deposition of misfolded α-synuclein (αsyn) in the enteric nervous system (ENS) is found in multiple neurodegenerative diseases. It is hypothesized that ENS synucleinopathy contributes to both the pathogenesis and non-motor morbidity in Parkinson's Disease (PD), but the cellular and molecular mechanisms that …

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Dopamine transporter activity regulates neuroimmune communication

Adithya Gopinath, Phillip M. Mackie, Emily Miller, Leah T. Phan et autres

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Who Knew? Dopamine Transporter Activity Is Critical in Innate and Adaptive Immune Responses

Emily Miller, Adithya Gopinath, Phillip M. Mackie, Leah T. Phan et autres

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Who Knew? Dopamine Transporter Activity Is Critical in Innate and Adaptive Immune Responses

Adithya Gopinath, Phillip M. Mackie, Leah T. Phan, Rosa Mirabel et autres

The dopamine transporter (DAT) regulates the dimension and duration of dopamine transmission. DAT expression, its trafficking, protein–protein interactions, and its activity are conventionally studied in the CNS and within the context of neurological diseases such as Parkinson’s Diseases and neuropsychiatric diseases such …

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The complex role of inflammation and gliotransmitters in Parkinson's disease

Adithya Gopinath, Phillip M. Mackie, Leah T. Phan, Malu Gámez Tansey et autres

Our understanding of the role of innate and adaptive immune cell function in brain health and how it goes awry during aging and neurodegenerative diseases is still in its infancy. Inflammation and immunological dysfunction are common components of Parkinson's disease (PD), both …

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DAT and TH expression marks human Parkinson’s disease in peripheral immune cells

Adithya Gopinath, Phillip M. Mackie, Basil Hashimi, Anna Marie Buchanan et autres

Abstract Parkinson’s disease (PD) is marked by a loss of dopamine neurons, decreased dopamine transporter (DAT) and tyrosine hydroxylase (TH) expression. However, this validation approach cannot be used for diagnostic, drug effectiveness or investigational purposes in human patients because midbrain tissue is …

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Functional characterization of the biogenic amine transporters on human macrophages

Phillip M. Mackie, Adithya Gopinath, Dominic M. Montas, Alyssa Nielsen et autres

Monocyte-derived macrophages (MDMs) are key players in tissue homeostasis and diseases regulated by a variety of signaling molecules. Recent literature has highlighted the ability for biogenic amines to regulate macrophage functions, but the mechanisms governing biogenic amine signaling in and around immune …

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Functional characterization of the biogenic amine transporter system on human macrophages

Phillip M. Mackie, Adithya Gopinath, Dominic M. Montas, Alyssa Nielsen et autres

Abstract Monocyte-derived macrophages are key players in tissue homeostasis and disease regulated by a variety of signaling molecules. Recent literature has highlighted the ability for biogenic amines to regulate macrophage functions, but the mechanisms governing biogenic amine signaling on and around immune …

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Author Correction: TNFα increases tyrosine hydroxylase expression in human monocytes

Adithya Gopinath, Martin Badov, Madison L. Francis, Gerry Shaw et autres

The original version of the published Article had a mistake in the Competing Interests section. The Competing Interests have been updated to the following: Malú Gámez Tansey is a co-inventor on the XPro1595 patent, and is a consultant to and has stock …

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