Daniel Ion

Inhibiting NHEJ: In-Silico Approach to Stratifying DNA-PK Inhibitors, Predicting Radio-Halogenation Potential of DNA-PK Inhibitors, and Assessing AlphaFold2 Prediction Accuracy

Dragoș Andrei Niculae, Florin-Vlad-Gabriel Crișu, Sabin Stoian, Daniel Ion et autres

BACKGROUND: The current study integrates AlphaFold2-based structural modeling of DNA-PKcs with an experimentally resolved DNA-PKcs structure, large-scale molecular docking of over 1500 known DNA-PK inhibitors, aiming to identify clinically relevant candidates for next-generation pharmacological delivery methods, evaluate receptor model suitability, and predict …

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Nanocomposite Biomaterials for Tissue-Engineered Hernia Repair: A Review of Recent Advances

Octavian Andronic, Alexandru Cosmin Palcău, Alexandra Bolocan, Alexandru Dinulescu et autres

Hernia repair is among the most frequent procedures in general surgery, traditionally performed with synthetic meshes such as polypropylene. While effective in reducing recurrence, these materials are biologically inert and often trigger chronic inflammation, fibrosis, pain, and impaired abdominal wall function, with …

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Cardiovascular Events and Preoperative Beta-Blocker Use in Non-Cardiac Surgery: A Prospective Holter-Based Analysis

Alexandru Cosmin Palcău, Liviu Ionuț Șerbănoiu, Livia Florentina Păduraru, Alexandra Bolocan et autres

Background and Objectives: The perioperative use of beta-blockers remains controversial due to conflicting evidence of their risks and benefits. The aim of this study was to evaluate the association between chronic beta-blocker (bb) therapy and perioperative cardiac events in non-cardiac surgeries using …

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Multidisciplinary Insights into Perioperative Cardiac Events in Non-Cardiac Surgery: an ECG Holter Monitoring Study

Alexandru Cosmin Palcău, Livia Florentina Păduraru, Alexandru Dinulescu, Florentina Mușat et autres

Background: Cardiovascular complications after non-cardiac surgery have a major impact on perioperative morbidity and mortality. Despite several scales and scores for assessing the preoperative cardiovascular status, an individualized assessment focused on each patient is mandatory. Aim: To identify the new cardiac events …

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Machine Learning-Assisted Drug Repurposing Framework for Discovery of Aurora Kinase B Inhibitors

Daniel Ion, George Mihai Nițulescu, Dragoș Paul Mihai

Background: Aurora kinase B (AurB) is a pivotal regulator of mitosis, making it a compelling target for cancer therapy. Despite significant advances in protein kinase inhibitor development, there are currently no AurB inhibitors readily available for therapeutic use. Methods: This study introduces …

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Balancing Precision and Practicality: SOFA

Laura Sorina Diaconu, Florentina Mușat, Daniel Ion, Dan Nicolae Păduraru et autres

Sepsis is a complex and multifaceted condition that remains a leading cause of morbidity and mortality worldwide. The sequential organ failure assessment (SOFA) and quick sequential organ failure assessment (qSOFA) scores are widely used to predict sepsis outcomes, but their utility varies …

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Atrial Fibrillation and Mortality after Gastrointestinal Surgery: Insights from a Systematic Review and Meta-Analysis

Alexandru Cosmin Palcău, Liviu Ionuț Șerbănoiu, Daniel Ion, Dan Nicolae Păduraru et autres

BACKGROUND: Heart failure, stroke and death are major dangers associated with atrial fibrillation (AF), a common abnormal heart rhythm. Having a gastrointestinal (GI) procedure puts patients at risk for developing AF, especially after large abdominal surgery. Although earlier research has shown a …

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Dynamics of serum cross‐neutralization capacity against SARS‐CoV‐2 Delta variant in convalescent COVID‐19 patients

Iulia Daniela Nedelcu, Paula Florian, Daniel Ion, Eliza Militaru et autres

Abstract The magnitude and breadth of the neutralizing antibody response against variants of concern following natural infection would provide valuable insights regarding the immune response induced by severe acute respiratory syndrome‐related coronavirus (SARS‐CoV‐2) infection. Herein, 25 patients were followed at 30 ±7 …

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Sentinel Node Biopsy Positivity: Is Axillary Dissection Always Necessary? – A Retrospective Analysis

Rahim al Moushaly, Dan Nicolae Păduraru, Octavian Andronic, Sorina Nechita et autres

Breast cancer remains a significant health concern, with predictions indicating a rise in global incidence. While the primary focus is on oncological radicality, the aesthetic and psychological impacts of surgical interventions, such as radical mastectomy, cannot be ignored. This study, conducted over …

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Lichenul plan oral – importanţa abordării interdisciplinare

Carmen-Larisa Nicolae, Elena Claudia Coculescu, Mihaela Tănase, Daniel Ion et autres

Oral lichen planus (OLP) is a mucocutaneous dermatosis that affects the oral mucosa. It is a chronic condition caused by an immunological mechanism involving a cell-mediated immune response, with the participation of the Langerhans cells, macrophages, and activated T lym­pho­cytes. In addition …

A Comprehensive Review of Inguinal Hernia Occurrence in Obese Individuals

Ruxandra ROSCA, Dan Nicolae Păduraru, Alexandra Bolocan, Florentina Mușat et autres

Inguinal hernia repair is one of the most commonly performed surgical activities worldwide. Given the circumstances, understanding and identifying the risk and the protective factors is an essential step in order to prevent, diagnose and treat such a common condition. For a …

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Sentinel node biopsy for personalized breast cancer management; advances and controversies

Daniel Ion, Octavian Andronic, Bogdan Socea, Alexandru Cosmin Palcău et autres

Sentinel lymph node biopsy (SLNB) has become the gold standard for axillary lymph node staging, providing valuable prognostic information while minimizing complications compared to axillary lymph node dissection. However, there are ongoing debates and controversies surrounding SLNB in specific cases. Studies have …

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