Orlando Swayne

Restorative Neurology, Rehabilitation and Brain Injury

Valerie L. Stevenson, Sara Ajina, Gerry Christofi, Rachel Farrell et autres

This chapter addresses the nature of disability, how it can best be ameliorated, which training techniques and medical treatments are most effective, particularly after single incident brain injury, and the organisational structures required for their optimal delivery. Rehabilitation is a complex intervention …

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The neurorehabilitation of people with Guillain-Barré Syndrome

Rachel Higgins, Orlando Swayne, L. O'Flaherty, Nicola Perkins

Guillain-Barré Syndrome (GBS), or Acute Inflammatory Demyelinating Polyneuropathy (AIDP) is a rare, acquired condition which can cause pain, sensory impairment and weakness in the limbs.The severity varies widely from mild non-disabling symptoms to complete flaccid tetraplegia, respiratory failure and autonomic instability.Those with …

Managing painful shoulder after neurological injury

Celine Lakra, Rachel Higgins, Ben Beare, Rachel Farrell et autres

Shoulder pain is common after neurological injury and can be disabling, lead to poor functional outcomes and increase care costs. Its cause is multifactoral and several pathologies contribute to the presentation. Astute diagnostic skills and a multidisciplinary approach are required to recognise …

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Raised Intracranial Pressure (Pseudotumour Cerebri) Associated With Severe Acute Respiratory Syndrome Coronavirus 2

Rubika Balendra, Matthew North, Saad Qutab, Hamid Aminy Raouf et autres

Balendra, Rubika MRCP, PhD; North, Matthew MRCP, PhD; Kumar, Guru MBBS, MRCP; Qutab, Saad MBBS, MRCP; Raouf, Hamid Aminy MRCP; Delamont, Shane S. FRACP, FRCP(Lond), MD; Chong, M. S. MD, FRCP; Hamdulay, Shahir S. PhD, FRCP; Rahman, Mushtaqur PhD, FRCP; Robertson, Fergus …

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Exploring the use of dopaminergic medication to treat hemispatial inattention during in‐patient post‐stroke neurorehabilitation

Orlando Swayne, Nikos Gorgoraptis, Alexander Leff, Sara Ajina

Hemispatial inattention (HSI), a lateralised impairment of spatial processing, is a common consequence of stroke. It is a poor prognostic indicator for functional recovery and interferes with the progress during in-patient neurorehabilitation. Dopaminergic medication has shown promise in improving HSI in the …

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Autonomic dysreflexia in spinal cord injury

Celine Lakra, Orlando Swayne, Gerry Christofi, Manishkumar Desai

Autonomic dysreflexia is a relatively common condition in people who have a spinal cord injury above the level of T6. It is a potentially life-threatening; without timely and effective treatment, it can have deleterious cardiophysiological and systemic consequences. It is therefore imperative …

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Severe neurological crisis in adult patients with Tyrosinemia type 1

Charlotte Dawson, Radha Ramachandran, Samreen Safdar, Elaine Murphy et autres

We report six adult patients with Tyrosinaemia type 1 (HT-1) who presented with recurrent porphyria-like neurological crises after discontinuation/interruption of 2-(2-nitro-4-trifluoro-methylbenzyol)-1,3 cyclohexanedione (NTBC) treatment. The crises were life-threatening for some of the patients, with respiratory muscle paralysis requiring ventilatory support, hemodynamic disturbance …

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17 Presentation of Capras syndrome in anti-NMDA receptor encephalitis: a neuro-rehabilitation approach

Richard Francis, Hui Ching, Himanshu Tyagi, Orlando Swayne et autres

Objectives/Aims Capgras syndrome is not often seen in neuro-rehabilitation and few case-reports of Capgras syndrome after anti-NMDA receptor encephalitis exist in literature. This case is relevant in light of how the Capgras sydrome and delusional beliefs affected this patient’s discharge planning, engagement …

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Enhancement of neuroplasticity by cortical stimulation

Orlando Swayne, John C. Rothwell

Non-invasive brain stimulation methods such as transcranial magnetic stimulation and transcranial direct current stimulation allow us to interact directly with activity in neural circuits in the brain. Work has shown that these methods can also lead to changes in the effectiveness of …

Bi-allelic JAM2 Variants Lead to Early-Onset Recessive Primary Familial Brain Calcification

Lucía Schottlaender, Rosella Abeti, Zane Jaunmuktane, Carol Macmillan et autres

Primary familial brain calcification (PFBC) is a rare neurodegenerative disorder characterized by a combination of neurological, psychiatric, and cognitive decline associated with calcium deposition on brain imaging. To date, mutations in five genes have been linked to PFBC. However, more than 50% …

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Hospital based rehabilitation services; Rising to the challenge of the COVID-19 pandemic

Valerie L. Stevenson, Rachel Farrell, Gita Ramdharry, Orlando Swayne et autres

Rehabilitation forms a critical component of the acute care pathway, helping to relieve pressure on the acute and frontline services.It is shown to be both effective and cost-effective, whether through improving independence and societal reintegration; or managing the impacts of long-term disability …

PO212 Prevalence of vitamin d deficiency in a complex neurological rehabilitation unit: a pilot study

Kiran Samra, Maryam Zahra, Orlando Swayne, Rachel Farrell

Vitamin D is essential for bone strength, cell growth and immune function. Sources include sunlight and diet. Deficiency causes fatigue, bone pain and weakness. Recognised in Multiple Sclerosis and spinal cord injury, little data exists in brain injury, stroke and patients in …

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