Xuting Zhang

Engineering Biomimetic Coronary Artery Equivalents for Kawasaki Disease Modeling and Drug Screening

Xuting Zhang, Changmin Shao, Yanke Wang, Andong Liu et autres

Kawasaki disease (KD) is an acute vasculitis that primarily affects the pediatric population, and the development of coronary artery lesions constituting its most severe clinical sequela. Although investigated for decades, the precise etiology and pathogenesis of this syndrome remains elusive. This critical …

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A Flow-Regulated Endothelial-Smooth Muscle Co-culture Vessel-on-a-Chip for Modeling Vascular Inflammation and Drug Evaluation

Yanke Wang, Changmin Shao, Xuting Zhang, Andong Liu et autres

Abstract Vascular inflammation drives vessel injury and cardiovascular disease progression; however, current in vitro models poorly reproduce vascular wall organization under flow. Here, we developed a flow-controlled vessel-on-a-chip (VOC) platform using a tunable collagen matrix, sequential seeding of primary human coronary artery …

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Advancing network pharmacology with artificial intelligence: the next paradigm in traditional Chinese medicine

Xin Shao, Yu Chen, Jinlu Zhang, Xuting Zhang et autres

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Microfluidic organ-on-a-chip for modeling coronary artery disease: Recent applications, limitations and potential

Yanke Wang, Andong Liu, Xuting Zhang, Xing Rong et autres

Coronary artery disease (CAD) encompasses a spectrum of pathologies driven by atherosclerosis, trauma, inflammation, or other etiologies that compromise coronary morphology and function, ultimately leading to myocardial ischemia and infarction. While organ-on-a-chip (OOC) technology has emerged as a transformative tool for cardiovascular …

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Trehalose metabolism contributed to abiotic stress tolerance of Larix gmelinii seedlings

Xuting Zhang, Yanxia Zhang, Mao-Lin Yan, Si Qin et autres

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Democratizing protein language model training, sharing and collaboration

Jin Su, Zhikai Li, Chenchen Han, Qingyan Yuan et autres

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A trimodal protein language model enables advanced protein searches

Jin Su, Yan He, Shiyu Jiang, Xibin Zhou et autres

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Long noncoding RNA LINC01215 represses differentiation and proliferation of keratinocytes via zinc finger 652 in atopic dermatitis

Quan Li, Hao Li, Qipeng Wei, Dongling Cai et autres

Objective Atopic dermatitis (AD) is a prevalent inflammatory disorder with high morbidity and seriously affects modern people. The pathogenesis of AD is complicated and involves multiple molecules. Long noncoding RNAs (lncRNAs) and zinc finger (ZNF) transcriptional factor (TF) are both essential regulators …

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Metabolomic Investigations Reveal Properties of Natural Low-Temperature Adaptation Strategies in Five Evergreen Trees

Bin Liu, T J Li, Xuting Zhang, Yanxia Zhang et autres

In northern China’s arid and semi-arid regions, evergreen trees demonstrate significant cold tolerance to natural low-temperature stress during winter. However, the metabolic strategies and their associated properties underlying their overwintering adaptation remain incompletely elucidated. This study aims to reveal the metabolic properties …

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Transcriptome and metabolome reveal the primary and secondary metabolism changes in Larix gmelinii seedlings under abiotic stress

Xuting Zhang, Xianling Gao, Bin Liu, Juan Wang et autres

BACKGROUND: Larix gmelinii is an excellent stress resistant coniferous tree species with a wide distribution and important economic and ecological value. However, at seedling stage, L. gmelinii is extremely susceptible to abiotic stresses, and systematic research on the adaptation mechanisms of L. …

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Comprehensive Proteome and Acetylome Analysis of Needle Senescence in Larix gmelinii

Xuting Zhang, Jinyuan Shan, Jiaxiu Wang, Yanxia Zhang et autres

Leaf senescence is essential for the growth and development of deciduous trees in the next season. Larix gmelinii, a deciduous coniferous tree, exhibits its most distinctive feature by turning yellow in the autumn and eventually shedding its leaves, resulting in significant changes …

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Quantifying High-Temperature and Drought Stress Effects on Soybean Growth and Yield in the Western Guanzhong Plain

Mei-Rong Li, Yue‐Feng Liu, Yuying Pan, Xuting Zhang et autres

High-temperature and drought events significantly impact crop growth and development. In the soybean-producing region of the Guanzhong Plain in China, understanding the dynamics of these climatic phenomena is vital for soybean yield preservation. Through a fixed-position observation experiment that analyzed four growth …

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