Shuaijun Lv

Probiotic interventions maintain intestinal barrier function and alleviate necrotizing enterocolitis by inhibiting ferroptosis in intestinal PMN-MDSCs

Meiqi Chen, Qing Zhao, Laiqin Peng, Z Chen et autres

Abstract Circulating polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) and gut probiotics are crucial for alleviating experimental necrotizing enterocolitis (NEC) in mice, yet the mechanisms linking intestinal PMN-MDSCs (iPMN-MDSCs) to specific microbiota remain unclear. Herein, we identified Lactobacillus ( L .) reuteri and L. …

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Gut microbiota-associated immunomodulation contributes to the protective effects of fluvastatin against endometriosis in a mouse model, accompanied by increased Akkermansia muciniphila abundance

Huilin Yang, Shuai Liu, Xia Chen, Chenxi Yin et autres

Background Endometriosis (EMs) is a chronic inflammatory disease characterized by tumor-like growth behavior and limited therapeutic options. Increasing evidence suggests that gut microbiota may contribute to EMs progression by promoting chronic inflammation and immune dysregulation. Fluvastatin, a lipid-lowering agent, exhibits anti-inflammatory, anti-tumor, …

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Gut microbial‐derived 3,4‐dihydroxyphenylacetic acid ameliorates reproductive phenotype of polycystic ovary syndrome

Li Pan, Li Xie, Huimin Zheng, Yinglin Feng et autres

Abstract Polycystic ovary syndrome (PCOS) is a prevalent endocrine and reproductive disorder affecting women of reproductive age. While the gut microbiota has been implicated in PCOS pathophysiology, the role of microbial‐derived metabolites as mediators of host–microbe interactions remains poorly defined. Here, we …

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Dietary-timing-induced gut microbiota diurnal oscillations modulate inflammatory rhythms in rheumatoid arthritis

Fopei Ma, Zhuang Li, Haihua Liu, Shixian Chen et autres

Dietary-timing-induced gut microbiota diurnal oscillations modulate inflammatory rhythms in rheumatoid arthritis

Fopei Ma, Zhuang Li, Haihua Liu, Shixian Chen et autres

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Blocking OLFM4/galectin-3 axis in placental polymorphonuclear myeloid-derived suppressor cells triggers intestinal inflammation in newborns

Shuaijun Lv, Meiqi Chen, Zhongjun Li, Zhengcong Huang et autres

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OLFM4 deficiency delays the progression of colitis to colorectal cancer by abrogating PMN-MDSCs recruitment

Ziyang Chen, Xiaogang Zhang, Zhe Xing, Shuaijun Lv et autres

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Continuous activation of polymorphonuclear myeloid-derived suppressor cells during pregnancy is critical for fetal development

Mengyu Shi, Ziyang Chen, Meiqi Chen, Jingping Liu et autres

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Treatment With Endothelin-A Receptor Antagonist BQ123 Attenuates Acute Inflammation in Mice Through T-Cell-Dependent Polymorphonuclear Myeloid-Derived Suppressor Cell Activation

Ziyang Chen, Xiaogang Zhang, Shuaijun Lv, Zhe Xing et autres

The endothelin-A receptor antagonist BQ123 is an effective treatment agent for hypertension and obese cardiomyopathy. However, the role of BQ123 in controlling acute inflammatory diseases and its underlying mechanisms are not well understood. Here, we showed that BQ123 activated polymorphonuclear myeloid-derived suppressor …

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TFF3 mediates the NF‐κB/COX2 pathway to regulate PMN‐MDSCs activation and protect against necrotizing enterocolitis

Jingping Liu, Qiong Yang, Ziyang Chen, Shuaijun Lv et autres

Abstract Intestinal trefoil factor 3 (TFF3) plays an important role in repairing the intestinal mucosa. However, the detailed mechanism regarding immune regulation by TFF3 is not well defined. Here, we reported that treatment of mouse BM cells and human peripheral blood mononuclear …

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Author response for "TFF3 mediates the NF-kappaB/COX2 pathway to regulate PMN-MDSCs activation and protect against necrotizing enterocolitis"

Jingping Liu, Qiong Yang, Ziyang Chen, Shuaijun Lv et autres

Author response for "TFF3 mediates the NF-kappaB/COX2 pathway to regulate PMN-MDSCs activation and protect against necrotizing enterocolitis"

Jingping Liu, Qiong Yang, Ziyang Chen, Shuaijun Lv et autres