Cathy R. Zhang

Abstract WP162: Shared Biological Pathways Among Genetic Variants Associated With White Matter Hyperintensity in CADASIL

Anne‐Katrin Giese, Cathy R. Zhang, Lisa Cloonan, Natalia S. Rost

Introduction: White matter hyperintensity (WMH) is a prominent neuroimaging phenotype commonly detected in patients with stroke as well as genetic disorders like cerebral autosomal dominant arteriopathy with subcortical infarcts and leukencephalopathy (CADASIL). We sought to identify biologically connected pathways between the genetic …

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Genome-wide meta-analysis of cerebral white matter hyperintensities in patients with stroke

Matthew Traylor, Cathy R. Zhang, Poneh Adib‐Samii, William J. Devan et autres

OBJECTIVE: For 3,670 stroke patients from the United Kingdom, United States, Australia, Belgium, and Italy, we performed a genome-wide meta-analysis of white matter hyperintensity volumes (WMHV) on data imputed to the 1000 Genomes reference dataset to provide insights into disease mechanisms. METHODS: …

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COX-2 rs20417 Polymorphism Is Associated with Stroke and White Matter Disease

Jamary Oliveira‐Filho, Ana C.P. Ornellas, Cathy R. Zhang, Luciana Mattos Barros Oliveira et autres

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Common variation in COL4A1/COL4A2 is associated with sporadic cerebral small vessel disease

Kristiina Rannikmäe, Gail Davies, Pippa A. Thomson, Steve Bevan et autres

OBJECTIVES: We hypothesized that common variants in the collagen genes COL4A1/COL4A2 are associated with sporadic forms of cerebral small vessel disease. METHODS: We conducted meta-analyses of existing genotype data among individuals of European ancestry to determine associations of 1,070 common single nucleotide …

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Genetic Architecture of White Matter Hyperintensities Differs in Hypertensive and Nonhypertensive Ischemic Stroke

Poneh Adib‐Samii, William J. Devan, Matthew Traylor, Silvia Lanfranconi et autres

BACKGROUND AND PURPOSE: Epidemiological studies suggest that white matter hyperintensities (WMH) are extremely heritable, but the underlying genetic variants are largely unknown. Pathophysiological heterogeneity is known to reduce the power of genome-wide association studies (GWAS). Hypertensive and nonhypertensive individuals with WMH might …

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Determinants of White Matter Hyperintensity Burden Differ at the Extremes of Ages of Ischemic Stroke Onset

Cathy R. Zhang, Lisa Cloonan, Kaitlin Fitzpatrick, Allison Kanakis et autres

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Abstract T P130: Determinants of White Matter Hyperintensity Burden Differ at the Extremes of Age of Ischemic Stroke Onset

Cathy R. Zhang, Lisa Cloonan, Kaitlin Fitzpatrick, Allison Kanakis et autres

Background: White matter hyperintensity (WMH) detected on MRI scans of patients with acute ischemic stroke (AIS) is associated with greater risk of infarct progression, poor post-stroke outcomes, and recurrent stroke. Age is strongly linked to risk of stroke and WMH. We hypothesized …

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Genetic contribution to white matter hyperintensity burden in early- and late-onset ischemic stroke patients

Cathy R. Zhang