Hong Zheng

Heat stress enhances gut microbial arginine catabolism to amplify MyD88-dependent inflammatory responses

Xianxi Ye, Qingpeng Cai, PAN YANGJIE, Minxuan Xu et autres

BACKGROUND: As global temperatures continue to rise, heat stress (HS) has emerged as a major health threat of growing concern. HS triggers systemic inflammation and multi-organ damage, but so far its molecular mechanisms remain unclear. In this study, we explored the potential …

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Deep Learning Approaches for Deformable Medical Image Registration: An In‐Depth Review and Analysis

Qingling Xia, Xinyue Huang, Gen Li, Hong Zheng et autres

ABSTRACT Deformable Medical Image Registration (DMIR) is integral to clinical workflows, aiding disease diagnosis, image‐guided interventions, and treatment monitoring. Recent advances in Deep Learning (DL) have propelled DMIR by enhancing registration efficiency and accuracy. This review systematically categorizes DL–based DMIR methods along …

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Progress in Pharmacokinetics, Pharmacological Effects, and Molecular Mechanisms of Swertiamarin: A Comprehensive Review

Hao-Xin Yang, Yu Hu, Rui Liang, Hong Zheng et autres

family, has been extensively utilized in traditional medicine systems, including Ayurveda, Traditional Chinese Medicine, and Tibetan medicine, for treating fever, diabetes, liver disorders, and inflammatory conditions. Pharmacokinetic studies reveal that SW exhibits rapid absorption but demonstrates low oral bioavailability due to the …

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Targeted sequencing and functional interrogation identified novel variant at 12q14.2 associated with risk of ovarian cancer in Han Chinese women

Yanrui Zhao, Wei Geng, Wei Liu, Lei Liu et autres

Chromosome 12q14.2 has been reported as a potential risk locus for epithelial ovarian cancer (EOC) in genome-wide association study (GWAS). We performed targeted sequencing around the rs11175194 at chromosome 12q14.2 and identified five potential risk variants. The association between these five variants …

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Mandibular molar protraction using round Australian wire and miniscrew anchorage with modified corticision in an adult with first molar loss: A case report

Qingjuan Shi, Qinglian Zhang, Hong Zheng

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A multicenter cross-sectional study on factors associated with caregiving appraisal in pediatric acute leukemia caregivers

Phoebe Abonyo Ouru, Hong Zheng, Zhi Lin, Minghua Yang

INTRODUCTION: Caring for pediatric acute leukemia (PAL) patients poses significant psychological challenges for family caregivers, impacting their well-being and caregiving capacity. This multicenter study aimed to assess caregivers' perception of their caregiving role using the revised Caregiving Appraisal Scale (rCAS) and identify …

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Progress in Pharmacokinetics, Pharmacological Effects, and Molecular Mechanisms of Swertiamarin: A Comprehensive Review

Hao-Xin Yang, Yu Hu, Rui Liang, Hong Zheng et autres

Swertiamarin (SW) is a natural iridoid glycoside primarily isolated from Gentianaceae family and has gained significant attention in natural product research in recent years. Pharmacological studies have demonstrated that swertiamarin possesses a wide range of pharmacological activities including antioxidant, anti-inflammatory, anti-tumor, antidiabetic, …

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Antibiotic‐induced IgA vasculitis: insights from a real‐world retrospective analysis and pharmacovigilance assessment

Hong Zheng, Leping Liu, Minghua Yang, Shengfeng Wang

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LKGDIR: A Deformable Image Registration Network with Large Kernel Ghost Module

Hong Zheng, Xin Jiang, Bin Jiang, Qingling Xia

Deformable image registration (DIR) holds significant importance in many fields. However, current deep learning (DL)-based registration methods still face several challenges, such as 1) inadequate extraction of global information of images due to the low receptive field and 2) large number of …

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[Rett syndrome-like phenotype caused by EEF1A2 gene in 2 children].

Y Z Wang, J K Zhang, Fanglin Zhang, Xiaoyan Jiang et autres

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A comprehensive review of deep learning for medical image segmentation

Qingling Xia, Hong Zheng, Dinghao Luo, Hong-An Tang et autres

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BCAA mediated microbiota-liver-heart crosstalk regulates diabetic cardiomyopathy via FGF21

Hong Zheng, Xi Zhang, Chen Li, Die Wang et autres

BACKGROUND: Diabetic cardiomyopathy (DCM) is one of leading causes of diabetes-associated mortality. The gut microbiota-derived branched-chain amino acids (BCAA) have been reported to play a central role in the onset and progression of DCM, but the potential mechanisms remain elusive. RESULTS: We …

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