Suguru Annen

Early antithrombin depletion after trauma is associated with biomarkers of endotheliopathy and systemic protein loss: a retrospective observational study

Hironori Matsumoto, Akihito Kan, Mitsuaki Takezawa, Tsunenori Tanabe et autres

BACKGROUND: Early antithrombin (AT) depletion after trauma may result from thrombin-related consumption, vascular leakage, and systemic protein loss. We examined the biomarker profile associated with early AT depletion and whether reduced AT activity identifies an adverse early injury phenotype. METHODS: In this …

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Age-specific assessment of initial hemoglobin levels and shock index for predicting life-saving interventions in pediatric blunt liver and spleen injuries

Takafumi Obara, Takashi Hongo, Atsuyoshi Iida, Kohei Tsukahara et autres

This study aimed to evaluate the effectiveness of combining initial hemoglobin levels with the shock index for predicting the need for life-saving interventions (LSI) in pediatric patients with blunt liver and spleen injuries (BLSI), specifically tailored to different age groups. This was …

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Association of endotheliopathy with coagulofibrinolytic reactions and disseminated intravascular coagulation after trauma: a retrospective observational study

Hironori Matsumoto, Suguru Annen, Naoki Mukai, Muneaki Ohshita et autres

We carried out a retrospective observational investigation to explore the association of endotheliopathy with coagulofibrinolytic reactions and the progression of disseminated intravascular coagulation (DIC) in adult trauma patients. We measured syndecan-1 (SDC-1), an indicator of endotheliopathy, and biomarkers of coagulofibrinolysis in 100 …

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Dysphagia in patients with severe COVID-19: a retrospective study

Rie Asayama, Kaori Tanaka‐Nishikubo, Masahiro Okada, Naoki Mukai et autres

To investigate dysphagia after extubation in patients with severe coronavirus disease 2019 (COVID-19). We retrospectively examined patients with severe COVID-19 treated in our hospital between August 2021 and March 2022. Feeding outcomes were categorized into two groups-(1) total oral intake, and (2) …

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Association of Contrast Extravasation Grade With Massive Transfusion in Pediatric Blunt Liver and Spleen Injuries: A Multicenter Retrospective Cohort Study

Morihiro Katsura, Shingo Fukuma, Akira Kuriyama, Yutaka Kondo et autres

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Circulating Syndecan-1 Levels Are Associated with Chronological Coagulofibrinolytic Responses and the Development of Disseminated Intravascular Coagulation (DIC) after Trauma: A Retrospective Observational Study

Hironori Matsumoto, Suguru Annen, Naoki Mukai, Muneaki Ohshita et autres

Background: The purpose of this study was to evaluate the association between endotheliopathy represented by high levels of circulating syndecan-1 (SDC-1) and coagulofibrinolytic responses due to trauma, which can lead to disseminated intravascular coagulation (DIC). Methods: We retrospectively evaluated 48 eligible trauma …

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Dynamic coagulofibrinolytic responses under long-term VV-ECMO management without anticoagulation in a COVID-19-ARDS patient: A case report

Hironori Matsumoto, Satoshi Kikuchi, Satoru Murata, Muneaki Ohshita et autres

RATIONALE: Venovenous extracorporeal membrane oxygenation (ECMO) is recommended for the treatment of critically ill patients with acute respiratory distress syndrome due to coronavirus disease 2019 (COVID-19). However, ECMO management can cause both bleeding and thrombotic complications. There are insufficient coagulofibrinolytic data for …

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Cricotracheostomy for patients with severe COVID-19: A case control study

Naoki Mukai, Masahiro Okada, Saki Konishi, Mitsuo Okita et autres

Background Tracheostomy is an important procedure for the treatment of severe coronavirus disease-2019 (COVID-19). Older age and obesity have been reported to be associated with the risk of severe COVID-19 and prolonged intubation, and anticoagulants are often administered in patients with severe …

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Laryngeal complications after endotracheal intubation and prone positioning in patients with coronavirus disease 2019

Shiori Aibara, Masahiro Okada, Kaori Tanaka‐Nishikubo, Rie Asayama et autres

Objectives: Laryngeal complications have been reported after endotracheal intubation and prone positioning in patients with critical coronavirus disease 2019 (COVID-19), but their association is unclear. In this study, we investigated the rate of laryngeal complications in patients with COVID-19 compared to an …

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FDP Fluctuation in Severe COVID-19 is Associated With the Development of Thrombotic or Bleeding Complications and Systemic Coagulopathy

Hironori Matsumoto, Satoshi Kikuchi, Satoru Murata, Muneaki Ohshita et autres

Abstract Purpose COVID-19 is sometimes associated with coagulation disorders. In such cases, patients developed elevated D‐dimer and fibrin degradation products (FDP) levels, both of which are associated with high risks of thromboembolic complications and poor prognosis. To date, time course changes of …

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ADAMTS13 activity decreases in the early phase of trauma associated with coagulopathy and systemic inflammation: a prospective observational study

Hironori Matsumoto, Jun Takeba, Kensuke Umakoshi, Satoshi Kikuchi et autres

BACKGROUND: We conducted a prospective observational study for investigating the changes in the 13th member of a disintegrin-like and metalloprotease with thrombospondin type 1 motif (ADAMTS13) and its association with the coagulofibrinolytic response in adult trauma patients. METHODS: In 39 trauma patients …

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Institutional Anticoagulation Protocol for Septic DIC is Associated with Differences in In-Hospital Mortality. J-SEPTIC DIC STUDY (A Nationwide Registry Study)

Keiko Tanaka, Hironori Matsumoto, Muneaki Ohshita, Suguru Annen et autres

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