Sarah L. Hulin-Curtis

A pseudotyped adenovirus serotype 5 vector with serotype 49 fiber knob is an effective vector for vaccine and gene therapy applications

Carly M. Bliss, Sarah L. Hulin-Curtis, Marta Williams, Mahulena Marušková et autres

Adenoviruses (Ads) have demonstrated significant success as replication-deficient (RD) viral vectored vaccines, as well as broad potential across gene therapy and cancer therapy. Ad vectors transduce human cells via direct interactions between the viral fiber knob and cell surface receptors, with secondary …

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A targeted single mutation in influenza A virus universal epitope transforms immunogenicity and protective immunity via CD4+ T cell activation

Sarah L. Hulin-Curtis, James K. Geary, Bruce J. MacLachlan, Danny M. Altmann et autres

CD4 + T cells are central to adaptive immunity. Their role in cross-protection in viral infections such as influenza and severe acute respiratory syndrome (SARS) is well documented; however, molecular rules governing T cell receptor (TCR) engagement of peptide-human leukocyte antigen (pHLA) …

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Supplementary Figures from Cancer Antigen Discovery Is Enabled by RNA Sequencing of Highly Purified Malignant and Nonmalignant Cells

Martin J. Scurr, Alex Greenshields-Watson, Emma Campbell, Michelle S. Somerville et autres

Supplementary Figures 1-7

Supplementary Tables from Cancer Antigen Discovery Is Enabled by RNA Sequencing of Highly Purified Malignant and Nonmalignant Cells

Martin J. Scurr, Alex Greenshields-Watson, Emma Campbell, Michelle S. Somerville et autres

Supplementary Tables 1-9

Supplementary Figures from Cancer Antigen Discovery Is Enabled by RNA Sequencing of Highly Purified Malignant and Nonmalignant Cells

Martin J. Scurr, Alex Greenshields-Watson, Emma Campbell, Michelle S. Somerville et autres

Supplementary Figures 1-7

Supplementary Tables from Cancer Antigen Discovery Is Enabled by RNA Sequencing of Highly Purified Malignant and Nonmalignant Cells

Martin J. Scurr, Alex Greenshields-Watson, Emma Campbell, Michelle S. Somerville et autres

Supplementary Tables 1-9

Data from Cancer Antigen Discovery Is Enabled by RNA Sequencing of Highly Purified Malignant and Nonmalignant Cells

Martin J. Scurr, Alex Greenshields-Watson, Emma Campbell, Michelle S. Somerville et autres

AbstractPurpose: Broadly expressed, highly differentiated tumor-associated antigens (TAA) can elicit antitumor immunity. However, vaccines targeting TAAs have demonstrated disappointing clinical results, reflecting poor antigen selection and/or immunosuppressive mechanisms. Experimental Design: Here, a panel of widely expressed, novel colorectal TAAs were identified by …

Data from Cancer Antigen Discovery Is Enabled by RNA Sequencing of Highly Purified Malignant and Nonmalignant Cells

Martin J. Scurr, Alex Greenshields-Watson, Emma Campbell, Michelle S. Somerville et autres

AbstractPurpose: Broadly expressed, highly differentiated tumor-associated antigens (TAA) can elicit antitumor immunity. However, vaccines targeting TAAs have demonstrated disappointing clinical results, reflecting poor antigen selection and/or immunosuppressive mechanisms. Experimental Design: Here, a panel of widely expressed, novel colorectal TAAs were identified by …

A Targeted Amino Acid Mutation in Influenza a Virus Universal Epitope Transforms Immunogenicity and Protective Immunity via CD4 T Cell Activation

Sarah L. Hulin-Curtis, James F. Geary, Bruce J. MacLachlan, Daniel Martin Altmann et autres

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The role and uses of antibodies in COVID-19 infections: a living review

David Oliver Scourfield, Sophie G. Reed, Max N. Quastel, Jennifer Alderson et autres

Coronavirus disease 2019 has generated a rapidly evolving field of research, with the global scientific community striving for solutions to the current pandemic. Characterizing humoral responses towards SARS-CoV-2, as well as closely related strains, will help determine whether antibodies are central to …

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Mucosal immune responses in COVID19 - a living review

Claire F. Pearson, Rebecca Jeffery, David Ahern, Hannah Almuttaqi et autres

COVID-19 was initially characterized as a disease primarily of the lungs, but it is becoming increasingly clear that the SARS-CoV2 virus is able to infect many organs and cause a broad pathological response. The primary infection site is likely to be a …

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Impact of obesity and SARS-CoV-2 infection: implications for host defence - a living review

Felix Clemens Richter, Aljawharah Alrubayyi, Alicia Teijeira Crespo, Sarah L. Hulin-Curtis

The role of obesity in the pathophysiology of respiratory virus infections has become particularly apparent during the current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, where obese patients are twice as likely to suffer from severe coronavirus disease 2019 (COVID-19) than …

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