Daniel A. Ritt

An in vitro BRAF activation assay elucidates molecular mechanisms driving disassembly of the autoinhibited BRAF state

Daniel A. Ritt, David Durrant, Matthew Drew, Juliana A. Martinez Fiesco et autres

The RAF kinases (ARAF, BRAF, and CRAF) are essential components of the RAS-ERK signaling pathway, which controls vital cellular processes and is frequently dysregulated in human disease. Notably, mutations that alter BRAF function are prominent drivers of human cancer and certain RASopathy …

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An In Vitro BRAF Activation Assay Elucidates Molecular Mechanisms Driving Disassembly of the Autoinhibited BRAF State

Daniel A. Ritt, David Durrant, Matthew Drew, Juliana A. Martinez Fiesco et autres

Abstract The RAF kinases (ARAF, BRAF and CRAF) are essential components of the RAS-ERK signaling pathway, which controls vital cellular processes and is frequently dysregulated in human disease. Notably, mutations that alter BRAF function are prominent drivers of human cancer and certain …

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Abstract PR06: Germline RASopathy mutations provide insights into the differential regulation of RAF family kinases

Russell Spencer-Smith, Elizabeth M. Terrell, Christine Insinna, Constance Agamasu et autres

Abstract The RAS-MAPK pathway is a hotspot for somatic mutations in human cancer and for germline mutations in the RASopathy developmental syndromes. Understanding the regulatory mechanisms that govern this pathway is critical for identifying new drug targets and establishing effective therapeutic approaches …

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Supplementary Figure S8.2 from TNIK Is a Therapeutic Target in Lung Squamous Cell Carcinoma and Regulates FAK Activation through Merlin

Pedro Torres‐Ayuso, Elvira An, Katherine M. Nyswaner, Ryan C. Bensen et autres

Uncropped immunoblots reported in this study.

Supplementary Tables from TNIK Is a Therapeutic Target in Lung Squamous Cell Carcinoma and Regulates FAK Activation through Merlin

Pedro Torres‐Ayuso, Elvira An, Katherine M. Nyswaner, Ryan C. Bensen et autres

Supplementary Tables

Supplementary Table 1 from Loss of MIG6 Accelerates Initiation and Progression of Mutant Epidermal Growth Factor Receptor–Driven Lung Adenocarcinoma

Tapan Kumar Maity, Abhilash Venugopalan, Ilona Linnoila, Constance M. Cultraro et autres

Supplementary Table 1. Identification of mice used is Western blots and immunoprecipitation experiments (M1-M20) and the mice used for the early time periods upon doxycycline induction.

Supplementary Figures 1 - 9 from Loss of MIG6 Accelerates Initiation and Progression of Mutant Epidermal Growth Factor Receptor–Driven Lung Adenocarcinoma

Tapan Kumar Maity, Abhilash Venugopalan, Ilona Linnoila, Constance M. Cultraro et autres

Supplementary Figure S1. Serial MRI imaging and lung histopathology analyses show rapid tumor progression of mutant EGFR-driven tumorigenesis in Mig6-/- background. Supplementary Figure S2. Representative photomicrographs of CC10rtTA/EGFRL858R/Mig6+/- mouse lungs at early stages of doxycycline treatment show variability of tumor progression. Supplementary …

Supplementary Methods, Figure Legends from Loss of MIG6 Accelerates Initiation and Progression of Mutant Epidermal Growth Factor Receptor–Driven Lung Adenocarcinoma

Tapan Kumar Maity, Abhilash Venugopalan, Ilona Linnoila, Constance M. Cultraro et autres

Supplementary Methods, Figure Legends

Supplementary Tables from TNIK Is a Therapeutic Target in Lung Squamous Cell Carcinoma and Regulates FAK Activation through Merlin

Pedro Torres‐Ayuso, Elvira An, Katherine M. Nyswaner, Ryan C. Bensen et autres

Supplementary Tables

Supplementary Figures from TNIK Is a Therapeutic Target in Lung Squamous Cell Carcinoma and Regulates FAK Activation through Merlin

Pedro Torres‐Ayuso, Elvira An, Katherine M. Nyswaner, Ryan C. Bensen et autres

Supplementary Figures S1-S7

Supplementary Figure S8.2 from TNIK Is a Therapeutic Target in Lung Squamous Cell Carcinoma and Regulates FAK Activation through Merlin

Pedro Torres‐Ayuso, Elvira An, Katherine M. Nyswaner, Ryan C. Bensen et autres

Uncropped immunoblots reported in this study.

Supplementary Figure S8.1 from TNIK Is a Therapeutic Target in Lung Squamous Cell Carcinoma and Regulates FAK Activation through Merlin

Pedro Torres‐Ayuso, Elvira An, Katherine M. Nyswaner, Ryan C. Bensen et autres

Uncropped immunoblots reported in this study.