2026
preprint
OpenAlex
Maibam R Singh, Christopher Gregg
Understanding the neural mechanisms underlying naturalistic decision-making requires chronic, high-quality neural recordings from distributed brain regions in freely behaving animals. However, existing silicon probe implants for mice are limited by weight, fragility, lack of independent probe adjustment, and poor suitability for long-term …
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Accès ouvert
2025
article
OpenAlex
Josue D Gonzalez Murcia, A. Cristina Rodriguez, Elliot Ferriss, Pablo J. Maldonado-Catala et autres
BACKGROUND: Alzheimer's disease (AD) is the 5th leading cause of death in adults over 65. Studies show that 40% of AD risk is modifiable, with metabolic factors playing a significant role, but the mechanisms are poorly defined. Metabolic pathways influence chromatin at …
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2025
article
OpenAlex
Elliott Ferris, Josue D. Gonzalez Murcia, Adriana Cristina Rodriguez, Susan Steinwand et autres
Extreme metabolic adaptations can elucidate genetic programs that govern mammalian metabolism. Here, we used convergent evolutionary changes in hibernating lineages to define conserved cis-regulatory elements (CREs) and metabolic programs. We characterized mouse hypothalamus gene expression and chromatin dynamics across fed, fasted, and …
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2025
article
OpenAlex
Susan Steinwand, Cornelia Stacher Hörndli, Elliott Ferris, Jared Emery et autres
Cis - regulatory elements (CREs) drive phenotypic diversity, yet how CREs are causally linked to function remains largely unclear. Our study elucidates functions for conserved cis elements associated with the evolution of mammalian hibernation and metabolic flexibility. Genomic analyses revealed topologically associated …
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2025
erratum
OpenAlex
Margaret A. Park, Christopher J. Whelan, Sabeen Ahmed, Tabitha Boeringer et autres
Dr [...].
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2024
article
OpenAlex
Jennifer B. Permuth, Margaret A. Park, Dung‐Tsa Chen, Toni L. Basinski et autres
Introduction: Cancer-associated cachexia (CC) is a progressive syndrome characterized by unintentional weight loss, muscle atrophy, fatigue, and poor outcomes that affects most patients with pancreatic ductal adenocarcinoma (PDAC). The ability to identify and classify CC stage along its continuum early in the …
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2024
article
OpenAlex
Margaret A. Park, Christopher J. Whelan, Sabeen Ahmed, Tabitha Boeringer et autres
For many patients, the cancer continuum includes a syndrome known as cancer-associated cachexia (CAC), which encompasses the unintended loss of body weight and muscle mass, and is often associated with fat loss, decreased appetite, lower tolerance and poorer response to treatment, poor …
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2024
preprint
OpenAlex
Susan Steinwand, Cornelia Stacher Hörndli, Elliott Ferris, Jared M. Emery et autres
Abstract Our study elucidates functional roles for conserved cis- elements associated with the evolution of mammalian hibernation. Genomic analyses found topologically associated domains (TADs) that disproportionately accumulated convergent genomic changes in hibernators, including the TAD for the Fat Mass & Obesity ( …
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2024
preprint
OpenAlex
Elliott Ferris, Josue D. Gonzalez Murcia, Adriana Cristina Rodriguez, Susan Steinwand et autres
Abstract Elucidating the genetic basis of mammalian metabolism could help define mechanisms central to health and disease. Here, we define conserved cis- regulatory elements (CREs) and programs for mammalian metabolic control. We delineate gene expression and chromatin responses in the mouse hypothalamus …
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Accès ouvert
2023
article
OpenAlex
Alicia Ravens, Cornelia N. Stacher-Hörndli, Jared M. Emery, Susan Steinwand et autres
Foraging in animals relies on innate decision-making heuristics that can result in suboptimal cognitive biases in some contexts. The mechanisms underlying these biases are not well understood, but likely involve strong genetic effects. To explore this, we studied fasted mice using a …
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2023
article
OpenAlex
Stephanie N. Kravitz, Elliott Ferris, Michael I. Love, Alun Thomas et autres
Genes are typically assumed to express both parental alleles similarly, yet cell lines show random allelic expression (RAE) for many autosomal genes that could shape genetic effects. Thus, understanding RAE in human tissues could improve our understanding of phenotypic variation. Here, we …
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2022
preprint
OpenAlex
Alicia Ravens, Cornelia N. Stacher-Hörndli, Jared M. Emery, Susan Steinwand et autres
ABSTRACT Foraging involves innate decision heuristics that are adapted for the wild but can cause economically suboptimal cognitive biases in some contexts. The mechanisms underlying cognitive biases are poorly understood but are likely genetic. Here, we investigate foraging in fasted mice using …
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