Jacob Rose

Distinct fibroblast and perivascular senotypes define spatial niches that regulate fibrosis

Alexandra N. Rindone, Sushma Nagaraj, Anna Cho, Maria Browne et autres

Fibrotic conditions contribute to significant global morbidity and mortality. Yet the underlying processes that orchestrate fibrosis remain poorly understood due to the cellular and spatial complexity of the stromal, immune, and vascular compartments that regulate fibrotic disease progression. Senescent cells (SnCs) have …

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Author Correction: Regulation of urea cycle by reversible high-stoichiometry lysine succinylation

Ran Zhang, Jingqi Fang, Xueshu Xie, Chris Carrico et autres

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p21+TREM2+ senescent macrophages fuel inflammaging and metabolic dysfunction-associated steatotic liver disease

Ivan Alexander Salladay-Perez, Itzetl Avila, Lizeth Estrada, Andreea Cristina Alexandru et autres

Cellular senescence drives chronic sterile inflammation during aging via the senescence-associated secretory phenotype, yet the senescent cell types responsible are poorly defined. Macrophages share multiple features of senescence, including inflammatory secretion, yet whether macrophages can adopt a senescent state remains unclear. Here …

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A multi-omics analysis of human fibroblasts overexpressing an Alu transposon reveals widespread disruptions in aging-associated pathways

Juan I. Bravo, Eyael Tewelde, Christina D. King, Joanna Bons et autres

During aging and cellular senescence, repetitive elements are frequently transcriptionally derepressed across species and cell types. Among these, the most abundant repeats by copy number in the human genome are Alu retrotransposons. Though Alu elements are often studied for their mutagenic potential, …

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A novel ECM human lung proteome atlas of healthy aging and COPD.

Delphine Beaulieu, Joanna Bons, Eileen Liu Huang, Mark A. Watson et autres

Aging is a complex biological process associated with impaired pulmonary function and an increased risk to develop chronic lung diseases. We applied comprehensive proteomic analysis on lung tissues of a human cohort of 20 healthy donors, aged 4 months to 95 years. …

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Tissue transglutaminase drives fibrin β-chain cross-linking: a novel fibrin modification observed in patients with trauma

Nana Kwame Kwabi Boateng, Riley Marie Wimberley, Jacob Rose, Angelo D’Alessandro et autres

ABSTRACT: Covalent cross-linking of fibrin by the plasma transglutaminase coagulation factor XIII (FXIII) is a key determinant of blood clot stability and function. FXIII-catalyzed formation of ε-N-(γ-glutamyl)-lysyl cross-links is restricted to the fibrin γ-chain and α-chain and follows thrombin-driven fibrin polymerization. Fibrinogen …

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Exosomes released from senescent cells and circulatory exosomes isolated from human plasma reveal aging-associated proteomic and lipid signatures.

Judith Campisi, Sandip Kumar Patel, Birgit Schilling, Mark A Watson et autres

Senescence emerged as significant mechanism of aging and age-related diseases, offering an attractive target for clinical interventions. Senescent cells release a senescence-associated secretory phenotype (SASP), including exosomes that may act as signal transducers between distal tissues, and propagate secondary senescence. However, the …

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Exosomes released from senescent cells and circulatory exosomes isolated from human plasma reveal aging-associated proteomic and lipid signatures

Sandip Kumar Patel, Joanna Bons, Jacob Rose, Jessie R. Chappel et autres

Senescence emerged as significant mechanism of aging and age-related diseases, offering an attractive target for clinical interventions. Senescent cells release a senescence-associated secretory phenotype (SASP), including exosomes that may act as signal transducers between distal tissues, and propagate secondary senescence. However, the …

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Concerted changes in Epithelium and Stroma: a multi-scale, multi-omics analysis of progression from Barrett’s Esophagus to adenocarcinoma

Michael K. Strasser, David L. Gibbs, Philippe D. Gascard, Joanna Bons et autres

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A multi-omics analysis of human fibroblasts overexpressing an Alu transposon reveals widespread disruptions in aging-associated pathways

Juan I. Bravo, Eyael Tewelde, Christina D. King, Joanna Bons et autres

ABSTRACT During aging and cellular senescence, repetitive elements are frequently transcriptionally derepressed across species and cell types. Among these, the most abundant repeats by copy number in the human genome are Alu retrotransposons. Though Alu elements are often studied for their mutagenic …

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A Fibroblast State Choreographs an Epithelial YAP-dependent Regenerative Program Essential to (Pre)malignancy via ECM-mediated Mechanotransduction

Deng Pan, Philippe D. Gascard, Joseph A. Caruso, Chira Chen‐Tanyolac et autres

heterotypic recombinant models of human b ronchial e pithelial c ells (hBECs) and fibroblasts. We demonstrate that injury-associated TGF-β signaling creates a fibroblast state dependent upon HSP47 upregulation. These fibroblasts accumulated collagen, thus elevating tissue stiffness and activating mechanosignaling that sustained YAP-dependent …

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A Comprehensive Multiomics Signature of Doxorubicin‐Induced Cellular Senescence in the Postmenopausal Human Ovary

Pooja Raj Devrukhkar, Mark A. Watson, Bikem Soygur, Fei Wu et autres

A major aging hallmark is the accumulation of cellular senescence burden. Over time, senescent cells contribute to tissue deterioration through chronic inflammation and fibrosis driven by the senescence-associated secretory phenotype (SASP). The human ovary is one of the first organs to age, …

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