Jacqueline A. Hubbard

Comparison of a Reformulated Automated Vitamin D Assay, Its Predecessor, and 2 Contemporary Formulations

K Aaron Geno, Yasel F Alvarez, Jacqueline A. Hubbard, Robert D Nerenz et autres

BACKGROUND: Historically, 25-hydroxyvitamin D (25OHD) assays have under- or over-recovered 25-hydroxyvitamin D2 (25OHD2), but assay manufacturers have modified their reagents to address this problem. In this study, we compared the second- and third-generation Roche assays as well as two contemporary offerings from …

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Modern drug testing in clinical laboratories: a narrative review of practical approaches and emerging technologies

Kamisha L. Johnson‐Davis, Siba J. Saker, Jacqueline A. Hubbard

Background and Objective: Clinical toxicology testing plays a critical role in patient care by supporting drug management, detecting toxic exposures, and monitoring medication adherence. With the increasing complexity of drug use patterns and the need for rapid, accurate diagnostics, toxicology laboratories must …

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Simplifying SARS-CoV-2 wastewater-based surveillance using an automated FDA EUA assay

S. Sathyanarayana, Diana M. Toledo, Torrey L. Gallagher, Gregory J. Tsongalis et autres

ABSTRACT Wastewater-based surveillance (WBS) can track the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in communities. Laboratory methods for this testing involve labor-intensive, multi-step processes. This study assessed the feasibility of performing WBS with an off-label use of an automated …

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Sample Preparation

Jacqueline A. Hubbard, Judith Stone, J. Grace van der Gugten

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Quality Assurance for LC-MS/MS Measurement Systems

Lorin M Bachmann, Deborah French, J. Grace van der Gugten, Jacqueline A. Hubbard

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Evaluation of Immunoassay Performance for the Detection of Opioids in Urine

Michael Walsh, Michael T. Kelliher, Jacqueline A. Hubbard, Mark A Cervinski

BACKGROUND: Immunoassay drug screens provide rapid analysis of urine for the presence of therapeutics and drugs of abuse. Compared to definitive (confirmatory) methods, immunoassays are prone to false-positive and -negative results. Laboratories generally rely on manufacturers' claims regarding method sensitivity and specificity; …

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Racism in Drug Testing

Jacqueline A. Hubbard, Kamisha L. Johnson‐Davis

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Analytical validation of a semi-automated methodology for quantitative measurement of SARS-CoV-2 RNA in wastewater collected in northern New England

Ashlee A. Robbins, Torrey L. Gallagher, Diana M. Toledo, Kenneth Chase Hershberger et autres

based epidemiology (WBE) can be used to monitor the community presence of infectious disease pathogens of public health concern such as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Viral nucleic acid has been detected in the stool of SARS-CoV-2-infected individuals. Asymptomatic …

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A-054 Comparison of a Reformulated Vitamin D Immunoassay, Its Predecessor, and Two Contemporary Formulations

K. Aaron Geno, Yasel F Alvarez, Mark A Cervinski, Jacqueline A. Hubbard et autres

Abstract Background We took advantage of our verification of a new biotin-resistant 25-hydroxyvitamin D (vitamin D) immunoassay formulation to compare analytical performance of the outgoing formulation and assays from Roche, Diasorin and Beckman. Liquid chromatography with tandem mass spectrometry (LCMS) was an …

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Driving Under the Influence of Cannabis: Impact of Combining Toxicology Testing with Field Sobriety Tests

Robert L. Fitzgerald, Anya Umlauf, Jacqueline A. Hubbard, Melissa Hoffman et autres

BACKGROUND: Cannabis is increasingly used both medically and recreationally. With widespread use, there is growing concern about how to identify cannabis-impaired drivers. METHODS: A placebo-controlled randomized double-blinded protocol was conducted to study the effects of cannabis on driving performance. One hundred ninety-one …

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An introduction from the Laboratory Developed Tests special issue guest editors

Melissa M. Budelier, Mark A. Marzinke, Jacqueline A. Hubbard

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Table S4 from Cannabinoids Promote Progression of HPV-Positive Head and Neck Squamous Cell Carcinoma via p38 MAPK Activation

Chao Liu, Sayed H. Sadat, Koji Ebisumoto, Akihiro Sakai et autres

List of relatively enriched pathways for each transcriptional component forming the Onco-GPS map.