Adaeze P. Ekwe

Cultivated corneal cells for bioengineering and tissue repair

Damien G. Harkin, Jennifer A. Walshe, Ceara C. McGowan, Adaeze P. Ekwe

au (code pays fourni par la source)

Contributors

Carla J. Abbott, Anas Abu-Dieh, Parinita Agrawal, Penelope J. Allen et autres

IL-6–mediated endothelial injury impairs antiviral humoral immunity after bone marrow transplantation

Ping Zhang, Peter Fleming, Christopher E. Andoniou, Olivia G. Waltner et autres

Endothelial function and integrity are compromised after allogeneic bone marrow transplantation (BMT), but how this affects immune responses broadly remains unknown. Using a preclinical model of CMV reactivation after BMT, we found compromised antiviral humoral responses induced by IL-6 signaling. IL-6 signaling …

au, us, gb (code pays fourni par la source)

Regulatory T cell-directed therapy for graft-versus-host disease

Adaeze P. Ekwe

The use of adoptively-transferred regulatory T cell (Tregs) for the treatment of graft-versus-host disease (GVHD) is limited by lack of clinically-applicable cell manufacturing methods. This study presents a good-manufacturing-practice compliant platform for the isolation, purification, expansion and gene-marking of Tregs, overcoming the …

Early Cytomegalovirus Reactivation after Allogenic Bone Marrow Transplantation Is Associated with the Loss of Recipient-Derived Humoral Immunity and Is Reduced By IL-6 Inhibition

Ping Zhang, Peter Fleming, Christopher E. Andoniou, José Paulo Martins et autres

Abstract Background: Interleukin-6 (IL-6) promotes the differentiation of pathogenic T cells and represents a dominant pathway of cytokine-dysregulation and graft-versus-host disease (GVHD). Cytomegalovirus (CMV) reactivation is a common and life-threatening infectious complication following allogenic bone marrow transplantation (BMT). The role of T …

au, us (code pays fourni par la source)

Clinical scale facs-sorting and expansion of regulatory t cells (TREGS) for phase i clinical trial

Adaeze P. Ekwe, Ramon Guerra Au, Benjamin A. McEnroe, Min Han Tan et autres

au (code pays fourni par la source)