HSD3B1 genotype identifies glucocorticoid responsiveness in severe asthma
Joe Zein, Benjamin M Gaston, Peter S. Bazeley, DeBoer MD et autres
Since their discovery ~70 years ago, glucocorticoids (GC) have been widely used to elicit a systemic anti-inflammatory response, and currently play a major role in the treatment of asthma and other inflammatory diseases (1). However, unresponsiveness to GC in some individuals is …