Lauren Marie Sparks

Adiposity and Cognitive Performance in Older Men and Women from the Study of Muscle, Mobility and Aging (SOMMA)

John J. Dubé, Haley N. Barnes, Zofia Ross, Neharika Murthy et autres

BACKGROUND: Aging is accompanied by changes in body composition and cognition. Although adiposity has been linked to metabolic dysfunction and dementia risk, associations with specific cognitive domains in later life remain unclear. METHODS: This cross-sectional study examined associations between adiposity and cognitive …

us (code pays fourni par la source)

Identification of a New Transcriptional Signature of Pre‐Adipocytes in Human Subcutaneous White Adipose Tissue

Katie L. Whytock, Adeline Divoux, Gilian Gunsch, Jia Nie et autres

OBJECTIVE: White adipose tissue (WAT) expansion occurs through generation of new adipocytes from adipose progenitor cells (APC). The objective of this study was to characterize and validate a new transcriptional profile of APC. METHODS: Single-cell (sc)/nuclei (sn) RNA-Seq was performed on nuclei …

us (code pays fourni par la source)

Rationale and Design of the HeartShare/AMP-HF Deep Phenotyping Study to Improve Understanding of Heart Failure With Preserved Ejection Fraction

Barry A. Borlaug, Julio A. Chirinos, Gregory D. Lewis, Margaret M. Redfield et autres

us, de (code pays fourni par la source)

Combined weight loss and exercise training alters skeletal muscle subcellular lipid localization and intermuscular adipose tissue cellular composition

Karin A. Zemski Berry, Amanda Garfield, Katie L. Whytock, Emily Macias et autres

Subcellular lipid accumulation and intermuscular adipose tissue (IMAT) accumulation are associated with insulin resistance, but the impact of combined weight loss and exercise training on localization of lipids and IMAT cellular composition is not known. Twenty-one adults with obesity (18F/3M; 46+2y; 35.0+0.9 …

Combined weight loss and exercise training alters skeletal muscle subcellular lipid localization and intermuscular adipose tissue cellular composition

Karin Zemski Berry, Amanda Garfield, Katie L. Whytock, Emily Macias et autres

Subcellular lipid accumulation and intermuscular adipose tissue (IMAT) accumulation are associated with insulin resistance, but the impact of combined weight loss and exercise training on localization of lipids and IMAT cellular composition is not known. Twenty-one adults with obesity (18F/3M; 46+2y; 35.0+0.9 …

Combined Weight Loss and Exercise Training Alters Skeletal Muscle Subcellular Lipid Localization and Intermuscular Adipose Tissue Cellular Composition

Karin A. Zemski Berry, Amanda Garfield, Katie L. Whytock, Emily Macias et autres

Subcellular lipid accumulation and intermuscular adipose tissue (IMAT) accumulation are associated with insulin resistance, but the impact of combined weight loss and exercise training on localization of lipids and IMAT cellular composition is not known. Twenty-one adults with obesity (18 female and …

us (code pays fourni par la source)

MicroRNA signatures of cardiorespiratory fitness (VO2peak) in older adults: Insights from the study of muscle, mobility, and aging

Genesio Mugambi Karere, Fang‐Chi Hsu, Russell T. Hepple, Paul M. Coen et autres

BACKGROUND: Peak oxygen consumption during exercise (VO2peak), is a direct measure of cardiorespiratory fitness (CF), a key indicator of physical function and overall health. However, the molecular changes that underpin VO2peak variation are not clear. Our objective is to understand the microRNA …

us (code pays fourni par la source)

Abstract 4904: Say it ain’t psoas: addressing edema in pancreatic cancer body composition analyses

Evan W. Davis, Margaret A. Park, Toni L. Basinski, J. Pablo Arnoletti et autres

Abstract Background: Image based body composition is the gold standard for assessing skeletal muscle area and quality in cancer patients. In patients with pancreatic ductal adenocarcinoma (PDAC), the decrease in muscle area and quality can be particularly profound. Yet image-based muscle assessment …

us (code pays fourni par la source)

Rest Activity Rhythms and Their Association with Cardiorespiratory Fitness and Walking Energetics in Older Adults: Study of Muscle, Mobility, and Aging

Melissa Lynn Erickson, TERRI L. BLACKWELL, Reagan E. Garcia, Theresa Mau et autres

PURPOSE: It is recognized that disruptions in circadian behavior, such as with shift work or jet lag, are associated with diminished health. This known relationship implies that people with stronger indices of circadian behavior will exhibit improved physiology. To address the association …

us, ie (code pays fourni par la source)

MicroRNA signatures of VO 2 peak in older adult participants of the Study of Muscle, Mobility and Aging

Genesio Mugambi Karere, Fang‐Chi Hsu, Russell T. Hepple, Paul M. Coen et autres

Abstract Background Peak oxygen consumption during exercise (VO 2 peak), is a direct measure of cardiorespiratory fitness (CF), a key indicator of physical function and overall health. However, the molecular changes that underpin VO 2 peak variation are not clear. Our objective …

us (code pays fourni par la source)

Leveraging real-world data to predict cancer cachexia stage, quality of life, and survival in a racially and ethnically diverse multi-institutional cohort of treatment-naïve patients with pancreatic ductal adenocarcinoma

Jennifer B. Permuth, Margaret A. Park, Dung‐Tsa Chen, Toni L. Basinski et autres

Introduction: Cancer-associated cachexia (CC) is a progressive syndrome characterized by unintentional weight loss, muscle atrophy, fatigue, and poor outcomes that affects most patients with pancreatic ductal adenocarcinoma (PDAC). The ability to identify and classify CC stage along its continuum early in the …

us (code pays fourni par la source)

Chrononutrition and Cardiometabolic Health in Older Adults From the Study of Muscle, Mobility and Aging (SOMMA)

Samaneh Farsijani, Ziling Mao, Peggy Mannen Cawthon, Stephen B. Kritchevsky et autres

Objectives: Dietary guidelines on cardiometabolic health emphasize the quantity and quality of food intake but often overlook meal timing. Given the critically low prevalence of optimal metabolic health (0.4%) in those ≥65 years, we examined the link between chrononutrition behaviors and cardiometabolic …

us, cn (code pays fourni par la source)