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Francisco J. Enguita, Suresh K. Alahari, Luca Agnelli, Raphaël Zemmour et autres
We are delighted to share with you our fifteenth Journal Club and highlight some of the most interesting papers published recently [...].
pt, us, it, fr, au, pl, gb, be, jp (code pays fourni par la source)
Current phase 3 clinical trials with a brain cancer treatment vaccine.Newly developed early phase Clinical trials with a glioblastoma treatment vaccine.
pl (code pays fourni par la source)
Klaudia Kiel, A Balakrishnan, Luiza Stanaszek, Szymon Hryhorowicz et autres
Abstract BACKGROUND Glioblastoma (GBM) remains a challenge for immunotherapy due to profound immune evasion and a highly suppressive tumor microenvironment. We developed EVOVs—extracellular vesicles derived from glioma stem-like cells (GSCs) infected with oncolytic HSV-1—serving as vaccine-like immune activators. We show that EVOVs …
pl, us (code pays fourni par la source)
Adrian Szczepaniak, Agnieszka Bronisz, Marta Zielińska, Marcin Grochowski et autres
Abstract Breast-to-brain metastatic (BTB-met) cancer remains a formidable challenge for modern medicine and science. As research on protein-coding genes has led to only incremental advances in developing anticancer therapies, the focus has increasingly shifted toward non-coding RNAs, particularly the recently discovered circular …
pl (code pays fourni par la source)
Klaudia Kiel, Raziye Piranlioglu, Jakub Godlewski, Agnieszka Bronisz
Cancer vaccines have emerged as a pivotal area of research in oncology, demonstrating significant promise in harnessing the immune system to combat cancer. Recent advancements in antigen identification and sequencing techniques have catalyzed the development of cancer vaccines whose goal is to …
pl, us (code pays fourni par la source)
Barbara Olejniczak, Arpita Balakrishnan, Justyna Augustyniak, Elżbieta Salińska et autres
The transient receptor potential (TRP) gene family is vital to cellular physiology, mediating ion flow across membranes and facilitating sensory signal transduction. This article examines the transcriptomic landscape of TRP genes, emphasizing their varying expression across organs, tissues, and cells, with a …
pl (code pays fourni par la source)
Arpita Balakrishnan, Gabriela Winiarek, Olga Hołówka, Jakub Godlewski et autres
The immunopeptidome, a diverse set of peptides presented by Major Histocompatibility Complex (MHC) molecules, is a critical component of immune recognition and response. This review article delves into the mechanisms of peptide presentation by MHC molecules, particularly emphasizing the roles of ncRNA-derived …
pl (code pays fourni par la source)
Agnieszka Bronisz, Klaudia Kiel, A Balakrishnan, Maciej Przybylski et autres
Abstract BACKGROUND Immunopeptide-based therapies offer the potential for cancer care breakthroughs, necessitating effective mass spectrometry utilization in preclinical research. Despite advancements in identifying cancer-specific antigens, personalized medicine faces challenges due to antigen scarcity, demanding heightened detection sensitivity. Additionally, limited patient tissue availability …
pl, us (code pays fourni par la source)
Adrian Szczepaniak, Agnieszka Bronisz, Jakub Godlewski
Abstract Breast-to-brain metastatic (BTB met) cancer constitutes a great challenge for modern medicine and science, and thus, a quest for the discovery of novel therapeutic targets is underway. As the research on protein-coding genes has brought only incremental progress in discovering such …
pl (code pays fourni par la source)
Adrian Szczepaniak, Agnieszka Bronisz, Jakub Godlewski
Abstract Introduction: Breast-to-brain metastatic (BTB met) cancer constitutes a great challenge for modern medicine and science. As the research on protein-coding genes brought only incremental progress in developing anticancer therapy, much attention is devoted to understanding the role of non-coding RNAs, including …
pl (code pays fourni par la source)
Klaudia Kiel, Sylwia Król, Agnieszka Bronisz, Jakub Godlewski
MicroRNA-128-3p (miR-128-3p) is a versatile molecule with multiple functions in the physiopathology of the human central nervous system. Perturbations of miR-128-3p, which is enriched in the brain, contribute to a plethora of neurodegenerative disorders, brain injuries, and malignancies, as this miRNA is …
pl (code pays fourni par la source)
Patrick Shiu, Mirolyuba Ilieva, Anja Holm, Shizuka Uchida et autres
We are delighted to share with you our twelfth Journal Club and highlight some of the most interesting papers published recently [...].
us, dk, pl, it, gb, au (code pays fourni par la source)
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