Joseph Brake

Abstract 2147 Copper-dependent Activation of Receptor Tyrosine Kinase Signaling

Grant Henrichs, Jaekwon Lee, Heejeong Kim, Joseph Brake et autres

Hydrogen sulfide increases intracellular oxygen and inhibits the HIF response

Joseph Brake, David A. Hanna, Roshan Kumar, Qianni Peng et autres

Oxygen (O 2 ) sensing by hypoxia-inducible factor (HIF) is a principal mechanism by which aerobic organisms adjust cellular energy metabolism and adapt to O 2 limitation. In this study, we show that hydrogen sulfide (H 2 S), a product of host …

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Histone deacetylase Hda1 is essential for leucine homeostasis in Saccharomyces cerevisiae

Wenxue Sun, Xiaobin Wu, wen Lu, Joseph Brake et autres

Power and poison: The intersections of H2S and O2 metabolism

Joseph Brake, Ruma V. Banerjee

S interplay.

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Rapid on-site detection of chromium contamination in foods using a naked-eye DMSA-AuNPs colorimetric sensor

Xiaoyong Hu, Yuhuan Qin, Jiahui Zhao, Joseph Brake et autres

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Hydrogen sulfide increases intracellular oxygen and regulates the HIF response

Joseph Brake, David A. Hanna, Roshan Kumar, Qianni Peng et autres

ABSTRACT O 2 sensing by hypoxia-inducible factor (HIF) is a principal mechanism by which aerobic organisms adjust cellular energy metabolism and adapt to O 2 limitation. In this study, we show that H 2 S, a product of host and microbial metabolism, …

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A novel colorimetric lead ion detection method using lead-2′3-dimercaptosuccinic acid chelates to catalyze etching of gold nanostars

Yuhuan Qin, Wenxue Sun, Joseph Brake, Qianqian Li et autres

Lead ions are an environmental pollutant and a threat to human health. Traditional methods for detecting lead ions suffer disadvantages such as being time-consuming and expensive, therefore there is a need to develop simpler and faster methods. We developed an optimized spectroscopic …

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Abstract 1212 Copper deficiency by excess fatty acids promote lipotoxicity

Joseph Brake, Grant Henrichs, Heejeong Kim, Jaekwon Lee

Copper (Cu) is an essential cofactor of several enzymes, including cytochrome oxidase (CCO), superoxide dismutase 1 (SOD1), and ceruloplasmin (Cp). These Cu-requiring enzymes play critical roles in metabolism, and patients and animal models with metabolic dysfunction-associated steatotic liver disease (MASLD) present low …

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Abstract 2205 Hydrogen sulfide increases intracellular oxygen to destabilize HIF and iron-sulfur cluster proteins

Joseph Brake, D.C. Hanna, Ruma V. Banerjee

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GEF1 Is a Novel Factor Regulating Nickel Ion Metabolism in Saccharomyces cerevisiae

Qianqian Li, Lixuan Zong, Joseph Brake, Chaoyang Luo et autres

Nickel is a trace element essential for human life. Currently, studies on the metabolism and function of nickel ions mainly focus on prokaryotes, while the role of nickel ions in eukaryotes is still being explored. In this study, we found for the …

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A Novel Colorimetric Lead Ion Detection Method Using Lead-2'3-Dimercaptosuccinic Acid Chelates to Catalyze Etching of Gold Nanostars

Yuhuan Qin, Wenxue Sun, Joseph Brake, Xiaobin Wu et autres

cn (code pays fourni par la source)

A method for the rapid detection of heavy metal mercury ions based on a novel mercury chelator N,N'-bis (2-mercaptoethyl) isophthalamide

Yali Wang, Shuangbo Zhang, Jiang Bian, Joseph Brake et autres

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