Accès ouvert
2026
article
OpenAlex
Rebeca González-Fernández, Andrea Martínez-López, Jairo Hernández, Pablo Martı́n-Vasallo et autres
PURPOSE: To analyse the microRNAs (miRNAs) present in blastocoel fluid (BF) and assess the relationship with blastocyst quality. METHODS: Seventy-two blastocysts from 57 women (25 IVF patients and 32 oocyte donors) undergoing IVF in a single private Fertility Center were included. Blastocyst …
es
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Accès ouvert
2025
article
OpenAlex
N.D. Pérez-Rodríguez, Rita Martín-Ramírez, Rebeca González-Fernández, María Del Carmen Maeso et autres
Background/Objectives: Truncating mutations in PALB2, a critical component of the BRCA1-PALB2-BRCA2 homologous recombination repair complex, are associated with increased risk and aggressiveness of breast cancer. The consequences of PALB2 truncation on the expression, localization, and functional dynamics of the scaffold protein IQGAP1 …
es
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Accès ouvert
2024
conference-abstract
OpenAlex
Julio Plata Bello, Helga Fariña-Jerónimo, Rita Martín-Ramírez, Carla M. Martín-Abreu et autres
Abstract BACKGROUND Androgen receptor (AR) activation appears to play a pathogenic role in glioblastoma. However, the impact of testosterone on sensitivity to temozolomide action has not been explored. The aim of the present work is to analyze the effect of testosterone on …
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Accès ouvert
2024
article
OpenAlex
Karen Álvarez-Tosco, Rebeca González-Fernández, María Ángeles González-Nicolás, Rita Martín-Ramírez et autres
BACKGROUND: Peripheral neuropathy (PN) constitutes a dose-limiting side effect of oxaliplatin chemotherapy that often compromises the efficacy of antineoplastic treatments. Sensory neurons damage in dorsal root ganglia (DRG) are the cellular substrate of PN complex molecular origin. Dehydropeptidase-1 (DPEP1) inhibitors have shown …
es
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Accès ouvert
2024
article
OpenAlex
Rebeca González-Fernández, Rita Martín-Ramírez, María-del-Carmen Maeso, Alberto Mariano Lázaro et autres
Gastrointestinal (GI) toxicity is a common side effect in patients undergoing oxaliplatin (OxPt)-based chemotherapy for colorectal cancer (CRC). Frequently, this complication persists in the long term and could affect the efficacy of the treatment and the patient's life quality. This long-term GI …
es
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Accès ouvert
2024
article
OpenAlex
Helga Fariña-Jerónimo, Rita Martín-Ramírez, Rebeca González-Fernández, Lilian Medina et autres
BACKGROUND: The androgen receptor (AR) has been demonstrated to play a role in the pathogenesis of glioblastoma; however, the implications of circulating testosterone levels in the biology of glioblastoma remain unknown. AIM: This study aimed to analyze the association between circulating testosterone …
es
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Accès ouvert
2024
article
OpenAlex
Roberta Repossi, Rita Martín-Ramírez, Fuensanta Gómez-Bernal, Lilian Medina et autres
Glioblastoma, the deadliest adult brain tumor, poses a significant therapeutic challenge with a dismal prognosis despite current treatments. Zonulin, a protein influencing tight junctions and barrier functions, has gained attention for its diverse roles in various diseases. This study aimed to preliminarily …
es
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Accès ouvert
2022
article
OpenAlex
Rebeca González-Fernández, María Ángeles González-Nicolás, Manuel Morales, Julio Cesar Grijalva Ávila et autres
The immunophilin FKBP51, the angiomotin AmotL2, and the scaffoldin IQGAP1 are overexpressed in many types of cancer, with the highest increase in leucocytes from patients undergoing oxaliplatin chemotherapy. Inflammation is involved in the pathogenesis of nephrotoxicity induced by platinum analogs. Cilastatin prevents …
es
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Accès ouvert
2022
article
OpenAlex
Helga Fariña-Jerónimo, Rita Martín-Ramírez, Rebeca González-Fernández, Lilian Medina-Vega et autres
Glioma cell lines and primary glioblastoma cells.Conclusion: The Zika/Lenti pseudotype system can transfer genes into known Glioma cell lines and primary tumor cells of GBM.Therefore, it may represent a complementary therapeutic option for the treatment of glioblastoma in the future.Overall, the system …
es
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Accès ouvert
2021
article
OpenAlex
Rita Martín-Ramírez, Rebeca González-Fernández, Jairo Hernández, Pablo Martı́n-Vasallo et autres
An excess of oxidative stress (OS) may affect several physiological processes fundamental to reproduction. SIRT1, SIRT6 and SIRT7 are involved in protection stress systems caused by OS, and they can be activated by antioxidants such as celastrol or melatonin. In this study, …
es
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Accès ouvert
2021
article
OpenAlex
Fabián Poletti, Rebeca González-Fernández, María-del-Pino García, Deborah Rotoli et autres
Knee osteoarthritis (OA) is one of the most prevalent chronic conditions affecting the adult population. OA is no longer thought to come from a purely biomechanical origin but rather one that has been increasingly recognized to include a persistent low-grade inflammatory component. …
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Accès ouvert
2021
article
OpenAlex
Rita Martín-Ramírez, Rebeca González-Fernández, Deborah Rotoli, Jairo Hernández et autres
Regulation of oxidative stress (OS) is important to prevent damage to female reproductive physiology. While normal OS levels may have a regulatory role, high OS levels may negatively affect vital processes such as folliculogenesis or embryogenesis. The aim of this work was …
es, it
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