Ruchi Kakar

The Regulation and Function of Hippo/ YAP Pathway in Cancer

Chinmoy Ghosh, Ruchi Kakar, Seline Torkamboor, Yue Sun

The Hippo/YAP signaling pathway is a key regulatory network that governs organ size, tissue homeostasis, cell proliferation, and cell polarity. Aberrant Hippo/YAP signaling contributes to the initiation and progression of multiple cancers, making this pathway an attractive therapeutic target. Although several agents …

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Type I gamma phosphatidylinositol phosphate kinase i5 suppresses YAP1 signaling

Chinmoy Ghosh, Ruchi Kakar, Matthew Bavuso, Huizhi Wang et autres

Dysregulation of the Hippo/Yes-associated protein (YAP) signaling pathway has been associated with several diseases, including cancer, neurological disorders, and cardiovascular conditions. However, the precise molecular mechanisms governing Hippo/YAP signaling are not fully understood, and additional regulators of this pathway need to be …

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Type I gamma phosphatidylinositol phosphate 5-kinase i5 controls cell sensitivity to interferon

Chinmoy Ghosh, Ruchi Kakar, Rosalie G. Hoyle, Zheng Liu et autres

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Phosphoinositide Signaling in Immune Cell Migration

Ruchi Kakar, Chinmoy Ghosh, Yue Sun

In response to different immune challenges, immune cells migrate to specific sites in the body, where they perform their functions such as defense against infection, inflammation regulation, antigen recognition, and immune surveillance. Therefore, the migration ability is a fundamental aspect of immune …

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A triad of telomerase, androgen receptor and early growth response 1 in prostate cancer cells

Sheeba Jacob, Sumeet U. Nayak, Ruchi Kakar, Uddhav K. Chaudhari et autres

Telomerase activation is one of the key mechanisms that allow cells to bypass replicative senescence. Telomerase activity is primarily regulated at the level of transcription of its catalytic unit- hTERT. Prostate cancer (PCa), akin to other cancers, is characterized by high telomerase …

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Proliferation and decidualization of endometrial stromal cells during embryo-attachment stage in bonnet monkeys (Macaca radiata)

Shruti Nimbkar-Joshi, Rajendraprasad R. Katkam, Ruchi Kakar, Priyanka Singh et autres

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Endometrial Receptivity: A Revisit to Functional Genomics Studies on Human Endometrium and Creation of HGEx-ERdb

Sonali R. Bhagwat, Darshan Shimoga Chandrashekar, Ruchi Kakar, Sravanthi Davuluri et autres

BACKGROUND: Endometrium acquires structural and functional competence for embryo implantation only during the receptive phase of menstrual cycle in fertile women. Sizeable data are available to indicate that this ability is acquired by modulation in the expression of several genes/gene products. However, …

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