Jiemei Guo

Identification of potential biomarkers and therapeutic targets for osteoarthritis associated with arginine and proline metabolism based on transcriptome sequencing and bioinformatics

Xiaohua Chen, Jun Liu, Ling Qiu, Yang Zhan et autres

Background and Objectives: Osteoarthritis (OA) is a chronic degenerative joint disease. Approximately 300 million people worldwide suffer from OA, which shows a high incidence in middle-aged and elderly populations, with a prevalence of 50% among individuals aged over 60 years. Its core …

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[Observation on the clinical efficacy of Huazhuo Sanjie Chubi decoction() in the treatment of low-grade inflammation in chronic gouty arthritis].

Si-Yuan Lin, Xiao-Hua Chen, Zijing Zheng, Fan Yang et autres

OBJECTIVE: decoction() in treating low-grade inflammation in chronic gouty arthritis (CGA). METHODS: , and courses of disease ranged from 4 to 21 years with an average of (8.50±4.15) years;treated with oral allopurinol. TCM syndrome score, Likert score for joint swelling and pain, …

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Huazhuo Sanjie Chubi Decoction attenuates gouty arthritis and kidney fibrosis by regulating urate transporters and JAK2/STAT3 pathway

Xiaomei Zhong, Siyuan Lin, Mei Zhong, Xueting Chen et autres

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Phytochemical characterization and pharmacological mechanisms of Huazhuo Sanjie Chubi Decoction in treating gouty arthritis: A multivariant approach

Xueting Chen, Xiaomei Zhong, Jiemei Guo, Tong Hong Jin et autres

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[Exploration of pharmacodynamic substances and potential mechanisms of Huazhuo Sanjie Chubi Decoction in treatment of gouty arthritis based on UPLC-Q-Exactive Orbitrap-MS technology and network pharmacology].

Yan Xiao, Ting Zhang, Yingjie Zhang, Bin Huang et autres

Based on ultra-high performance liquid chromatography-quadrupole-Exactive Orbitrap mass spectrometry(UPLC-Q-Exactive Orbitrap-MS) technology and network pharmacology, this study explored the pharmacodynamic substances and potential mechanisms of Huazhuo Sanjie Chubi Decoction in the treatment of gouty arthritis(GA). UPLC-Q-Exactive Orbitrap-MS technology was used to identify the …

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[Zhuanggu Jianxi Decoction reduces synovial tissue inflammation in human knee osteoarthritis by regulating LXRs/NF-κB signaling pathway].

Yan Xiao, Jun Liu, Peng Chen, Meiling Wang et autres

This study aims to explore the mechanism of Zhuanggu Jianxi Decoction in reducing synovial tissue inflammation in human knee osteoarthritis(KOA) via the liver X receptors(LXRs)/nuclear factor(NF)-κB signaling pathway. The synovial tissue samples were collected from 5 healthy volunteers and 30 KOA synovitis …

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Exploring the ceRNA Network of Differentially Expressed lncRNAs in Gout: A Bioinformatics Analysis

Jiemei Guo, Xiaopeng Fu, Siwei Peng, Yan Xiao et autres

Abstract Objective: To elucidate the regulatory mechanisms of the competing endogenous RNA (ceRNA) network associated with gout, and to investigate potential targets for diagnosis and treatment of this disease. Methodology: The GSE160170 dataset was downloaded from the GEO database, annotated, and gene …

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Effect of Zhuanggu Jianxi Decoction on Synovitis in Knee Osteoarthritis Rabbits via LXRs/NF-κB Pathway

Peng Chen, Jiemei Guo, Yan Xiao, Jianhui WANG et autres

Objective To study the intervention effect and mechanism of Zhuanggu Jianxi decoction on synovitis in knee osteoarthritis (KOA) rabbits via the inflammatory regulation of synovial tissue and the expression of key node proteins in LXRs/NF-κB pathway. Methods Blank serum and drug-containing serum …

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Chinese Medicine Involving Triple Rehabilitation Therapy for Knee Osteoarthritis in 696 Outpatients: A Multi-Center, Randomized Controlled Trial

Jiemei Guo, Yan Xiao, Tang-yan Cai, Jianhui Wang et autres

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Traditional Chinese Medicine Involving Triple Rehabilitation Therapy for Knee Osteoarthritis in 696 Outpatient Cases: A Multi-center Randomized Controlled Trial

Jiemei Guo, Tang-yan Cai, Yan Xiao, Jianhui Wang et autres

Abstract Background: The treatment and rehabilitation of knee osteoarthritis (KOA) are important. This trial was designed to determine the effects of Traditional Chinese Medicine (TCM) involving triple rehabilitation therapy for KOA on the progression of this disease to help expand the use …

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Effect of Electroacupuncture Combined with Traditional Chinese Medicine Fumigation and Traditional Exercises in Treating Knee Osteoarthritis Rehabilitation

Fangzhou Teng, Ya-ju Zhu, Tang-yan Cai, Lulu Huang et autres

Objective:To observe the rehabilitation effect of electroacupuncture combined with traditional Chinese medicine fumigation and traditional exercises in knee osteoarthritis (KOA) treatment.Methods:A total of 78 KOA patients were randomly assigned to trial group and control group, with 39 cases in each group. All …

Effect of TongFengNing Decoction on Uric Acid Levels and Xanthine Oxidase Activity in Hyperuricemia Rats

Jianhui Wang, Jiemei Guo, Baolin Li, Fangzhou Teng et autres