Ross A. Jones

Neuromuscular junction failure in sarcopenia is linked to NaV1.4 loss and reversed by ClC-1 inhibition

W. David Arnold, Jeanette J. Morgen, Pernille Bogetofte Thomasen, Martin Broch-Lips et autres

Sarcopenia is the age-related loss of muscle strength and size that leads to mobility limitations and loss of independence in older adults. The underlying cellular mechanisms remain unclear, and treatments are limited. As the critical interface between the nervous system and muscle, …

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Protocol for applying expansion microscopy to the study of mammalian neuromuscular junctions

Abdullah H. Al Ramadan, Thomas M. D. Sheard, Abrar Alhindi, Philippa Rust et autres

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Threshold-Anchored Mechanomyography Metrics for Patient Stratification in Spinal Decompression: Associations with Early Pain Outcomes

Muwaffak Abdulhak, Ross A. Jones, Derek Nay, Christopher Wybo

Background/Objectives: Spinal decompression surgery shows variable outcomes, with reoperation rates up to 37.5%. Surgeons lack objective intraoperative tools to assess decompression adequacy. Mechanomyography (MMG) measures nerve excitability through mechanical muscle responses to electrical stimulation. While compressed nerves require higher stimulation thresholds, optimal …

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Expansion microscopy reveals nano-scale insights into the human neuromuscular junction

Abdullah H. Al Ramadan, Thomas M. D. Sheard, Abrar Alhindi, Philippa Rust et autres

The neuromuscular junction (NMJ) is a specialized synapse that relays signals from the lower motor neuron to the skeletal muscle. Here, we detail the development and application of expansion microscopy (ExM) as a highly accessible, relatively cheap, powerful, and reproducible tool with …

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Comment on ‘Neuromuscular Impairment at Different Stages of Human Sarcopenia’ by Sarto et al.

Ross A. Jones, Abdullah H. Al Ramadan, Shahd Qutifan, Thomas H. Gillingwater

We read with interest the paper entitled 'Neuromuscular impairment at different stages of human sarcopenia' by Sarto et al. [1], which has used a variety of assessment approaches to innovatively investigate neuromuscular impairment in older human subjects.This study undoubtedly represents an important …

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The Wade Programme in surgical anatomy: educational approach and 10-year review

Ross A. Jones, Jeremy W. Mortimer, Aidan Fitzgerald, Rowan W. Parks et autres

BACKGROUND: Against a background of significant changes in UK medical education at both undergraduate and postgraduate levels, the Royal College of Surgeons of Edinburgh (RCSEd) established the Wade Programme in Surgical Anatomy in 2012, as a means of supporting the study of …

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Long-term muscle-specific overexpression of DOK7 in mice using AAV9-tMCK-DOK7

Yuting Huang, Hannah R. Crick, Helena Chaytow, Dinja van der Hoorn et autres

Neuromuscular junction (NMJ) dysfunction underlies several diseases, including congenital myasthenic syndromes (CMSs) and motor neuron disease (MND). Molecular pathways governing NMJ stability are therefore of interest from both biological and therapeutic perspectives. Muscle-specific kinase (MuSK) is necessary for the formation and maintenance …

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Cover Image, Volume 49, Issue 4

Abrar Alhindi, Megan Shand, Hannah Smith, Ana S. Leite et autres

The cover image is based on the Original Article Neuromuscular junction denervation and terminal Schwann cell loss in the hTDP-43 overexpression mouse model of amyotrophic lateral sclerosis by Abrar Alhindi et al., https://doi.org/10.1111/nan.12925. Image Credit: Abrar Alhindi and Helena Chaytow.

Neuromuscular junction denervation and terminal Schwann cell loss in the hTDP‐43 overexpression mouse model of amyotrophic lateral sclerosis

Abrar Alhindi, Megan Shand, Hannah Smith, Ana S. Leite et autres

Abstract Aims Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with complex aetiology. Despite evidence of neuromuscular junction (NMJ) denervation and ‘dying‐back’ pathology in models of SOD1‐dependent ALS, evidence in other genetic forms of ALS is limited by a lack of …

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Metformin protects against vascular calcification through the selective degradation of Runx2 by the p62 autophagy receptor

Kanchan Phadwal, Eve Koo, Ross A. Jones, Rachael O. Forsythe et autres

Vascular calcification is associated with aging, type 2 diabetes, and atherosclerosis, and increases the risk of cardiovascular morbidity and mortality. It is an active, highly regulated process that resembles physiological bone formation. It has previously been established that pharmacological doses of metformin …

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A method to identify, dissect and stain equine neuromuscular junctions for morphological analysis

Stephen D. Cahalan, Justin Perkins, Ines Boehm, Ross A. Jones et autres

Morphological study of the neuromuscular junction (NMJ), a specialised peripheral synapse formed between a lower motor neuron and skeletal muscle fibre, has significantly contributed to the understanding of synaptic biology and neuromuscular disease pathogenesis. Rodent NMJs are readily accessible, and research into …

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Recognising the potential of large animals for modelling neuromuscular junction physiology and disease

Stephen D. Cahalan, Ines Boehm, Ross A. Jones, Richard J. Piercy

The aetiology and pathophysiology of many diseases of the motor unit remain poorly understood and the role of the neuromuscular junction (NMJ) in this group of disorders is particularly overlooked, especially in humans, when these diseases are comparatively rare. However, elucidating the …

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