Angela Gomez‐Simmonds

Molecular epidemiology and associated treatment outcomes of third generation cephalosporin-resistant enterobacterales causing pneumonia in intensive care unit patients

Clare DeLaurentis, Todd W Hokunson, Brian Nelson, Medini K. Annavajhala et autres

Abstract Background Infections caused by third generation cephalosporin (3GC)-resistant Enterobacterales (Ceph-RE) are rising in incidence. 3GC resistance may be due to production of extended-spectrum beta-lactamase (ESBL) or AmpC enzymes. However, studies evaluating the molecular epidemiology of Ceph-RE causing pneumonia and their antibiotic …

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Interconnected reservoirs of multidrug-resistant bacteria and plasmids within the hospital built environment

Medini K. Annavajhala, Todd W Hokunson, Kasiani Terzoglou, Anne‐Catrin Uhlemann et autres

Abstract Hospital sinks and wastewater streams are hotspots for contamination and colonization with multidrug-resistant Gram-negative bacteria (MDR-GNB). However, longitudinal studies investigating the population dynamics of environmental MDR-GNB and links between patients and the environment are lacking, especially in non-outbreak settings. Here we …

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Carbapenemases: epidemiology, detection and management in a changing global landscape

Nenad Maćešić, Patrick N A Harris, Yin Mo, Angela Gomez‐Simmonds

Abstract Carbapenemase-producing Gram-negative bacteria are a growing threat to last-line beta-lactam (BL) therapy and are now established across Enterobacterales, Pseudomonas aeruginosa and Acinetobacter baumannii. Since the first reports in the 1980s, carbapenemase genes have disseminated internationally through plasmids, transposons and integrons and …

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P-1134. Hospital Sink Drains and Wastewater Harbor Distinct Yet Overlapping Multidrug-Resistant Bacterial Species and Resistance Gene Plasmids

Medini K. Annavajhala, Kasiani Terzoglou, Todd W Hokunson, A. Uhlemann et autres

Abstract Background Multidrug-resistant bacteria (MDRB) have been shown to disseminate and persist within the hospital environment, potentially increasing risk of infection in hospitalized patients. Extended spectrum beta-lactamase-producing and carbapenem-resistant Enterobacterales (ESBLE, CRE) have been identified in hospital sinks and wastewater (WW) primarily …

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The rise and global spread of IMP carbapenemases (1996-2023): a genomic epidemiology study

Ben Vezina, Bhargava Reddy Morampalli, Hoai-An Nguyen, Angela Gomez‐Simmonds et autres

Abstract Infections caused by carbapenemase-producing organisms are a global health threat. IMP carbapenemases are one of the key drivers of these infections but little is known regarding their global epidemiology. We analyse three decades of bla IMP gene spread using sequence data …

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Fecal Microbiota and Bile Acid Profiles in Early-Stage Hepatocellular Carcinoma: A Matched Case-Control Study

Yael R. Nobel, Heekuk Park, Alice Tillman, Dwayne Seeram et autres

INTRODUCTION: Early identification of hepatocellular carcinoma (HCC) is critical to reduce mortality. Diagnostic tools are limited for early disease. Intestinal microbiota may contribute to HCC risk directly and through metabolites, particularly bile acids (BAs), offering potential noninvasive biomarkers. METHODS: This was a …

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The rise and global spread of IMP carbapenemases (1996–2023): a genomic epidemiology study

Ben Vezina, Bhargava Reddy Morampalli, Hoai-An Nguyen, Angela Gomez‐Simmonds et autres

Abstract Background IMP carbapenemases confer extensive drug resistance and are increasingly noted worldwide. Despite this, little is known regarding the global epidemiology of IMP carbapenemases. Methods We comprehensively identified bla IMP genes in all publicly available bacterial genomes, then systematically analysed the …

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The Clinical and Molecular Characteristics of Community-Associated Staphylococcus aureus Bacteremia in Persons who Inject Drugs at a New York City Tertiary Care Facility During the Opioid Epidemic

Sherif Shoucri, Nicholas Blair, Dwayne Seeram, Angela Gomez‐Simmonds et autres

Abstract Background Staphylococcus aureus (SA) bacteremia is a morbid complication of injection drug use (IDU), yet little is known about the biological and clinical factors that drive morbidity due to these infections in persons who inject drugs (PWID). Methods We reviewed all …

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P-1340. Genetic Factors Associated with Cefepime and Piperacillin/Tazobactam Resistance in Clinical Extended-Spectrum Beta-Lactamase-Producing Enterobacterales from the Intensive Care Unit

Todd W Hokunson, Medini K. Annavajhala, Anne‐Catrin Uhlemann, Angela Gomez‐Simmonds

Abstract Background Extended-spectrum β-lactamase (ESBL)-producing Enterobacterales (ESBLE) are common pathogens in intensive care units (ICUs) causing infection at a range of body sites. While carbapenems are considered first-line agents, non-carbapenem beta-lactams such as piperacillin/tazobactam (TZP) and cefepime (FEP) are often used to …

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Genomic epidemiology of carbapenem-resistant Enterobacterales at a New York City hospital over a 10-year period reveals complex plasmid-clone dynamics and evidence for frequent horizontal transfer ofblaKPC

Angela Gomez‐Simmonds, Medini K. Annavajhala, Dwayne Seeram, Todd W Hokunson et autres

Transmission of carbapenem-resistant Enterobacterales (CRE) in hospitals has been shown to occur through complex, multifarious networks driven by both clonal spread and horizontal transfer mediated by plasmids and other mobile genetic elements. We performed nanopore long-read sequencing on CRE isolates from a …

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Mo1923 GUT ACQUISITION OF MULTIDRUG RESISTANT GRAM-NEGATIVE BACTERIA IN THE INTENSIVE CARE UNIT: A SYSTEMATIC REVIEW AND META-ANALYSIS

Madison R. Heath, Angela Gomez‐Simmonds, Thomas P. Lodise, Daniel E. Freedberg

Sa1924 TIMING AND CLINICAL RISK FACTORS FOR EARLY ACQUISITION OF GUT PATHOGEN COLONIZATION WITH MULTIDRUG RESISTANT ORGANISMS IN THE INTENSIVE CARE UNIT

Loren Shamalov, Madison R. Heath, Elissa Lynch, Daniel A. Green et autres