Esther Crawley

Fatigue in children and young people up to 24 months after infection with SARS-CoV-2

Alvin Richards‐Belle, Roz Shafran, Natalia Rojas, Terence Stephenson et autres

Persistent fatigue is common following acute SARS-CoV-2 infection. Little is known about post-infection fatigue trajectories in children and young people (CYP). This paper reports on a longitudinal analysis of the Children and Young People with Long COVID study. SARS-CoV-2-positive participants, aged 11-to-17-years …

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Online treatment of myalgic encephalomyelitis / chronic fatigue syndrome in adolescents: a parallel groups randomised controlled trial comparing specialist cognitive behaviour therapy to activity management

Georgia Treneman-Evans, Beverly A. Shirkey, Madeleine Cochrane, Ammar Annaw et autres

Purpose: Online delivery may improve access to specialist treatment services for paediatric Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS). Methods: This parallel group randomised controlled trial, with no masking of allocated treatment, compared the clinical and cost-effectiveness of two interventions delivered online: …

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A 24-month National Cohort Study examining long-term effects of COVID-19 in children and young people

Terence Stephenson, Snehal M. Pinto Pereira, Manjula D. Nugawela, Emma Dalrymple et autres

BACKGROUND: Some children and young people (CYP) infected with SARS-COV-2 experience impairing symptoms post-infection, known as post-COVID-19 condition (PCC). Using data from the National Long COVID in Children and Young People (CloCk) study, we report symptoms and their impact up to 24-months …

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Predicting post-COVID-19 condition in children and young people up to 24 months after a positive SARS-CoV-2 PCR-test: the CLoCk study

Manjula D. Nugawela, Terence Stephenson, Roz Shafran, Trudie Chalder et autres

BACKGROUND: Predicting which children and young people (CYP) are at the highest risk of developing post-COVID-19 condition (PCC) could improve care pathways. We aim to develop and validate prediction models for persistent PCC up to 24 months post-infection in CYP. METHODS: CYP …

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Comparison of cognitive behaviour therapy versus activity management, both delivered remotely, to treat paediatric chronic fatigue syndrome/myalgic encephalomyelitis: the UK FITNET-NHS RCT

Esther Crawley, Emma Anderson, Madeleine Cochrane, Beverly A. Shirkey et autres

Design: Parallel-group randomised controlled trial. Methods: Adolescents aged 11-17 years, diagnosed with myalgic encephalomyelitis/chronic fatigue syndrome and with no local specialist treatment centre, were referred to a specialist service in South West England. Interventions: Fatigue In Teenagers on the interNET in the …

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OP-103 Severe ME/CFS in children: a British paediatric surveillance unit study

Alexander Peter Royston, Manmita Rai, Amberly Brigden, Sarah Burge et autres

Aim Severe myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS) is a poorly understood condition which significantly impacts education, development and quality of life in children and young people. We conducted a population-wide surveillance study to determine the prevalence and incidence rate of …

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Post-Covid-19 condition (Long Covid) in children and young people 12 months after infection or reinfection with the Omicron variant: a prospective observational study

Snehal M. Pinto Pereira, Manjula D. Nugawela, Terence Stephenson, Paul Foret-Bruno et autres

Our previous study in children and young people (CYP) at 3- and 6-months post-infection showed that 12-16% of those infected with the Omicron (B.1.1.529) variant of SARS-CoV-2 met the research definition of Long Covid, with no differences between first-positive and reinfected CYP. …

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Graded exercise therapy compared to activity management for paediatric chronic fatigue syndrome/myalgic encephalomyelitis: pragmatic randomized controlled trial

Daisy Gaunt, Amberly Brigden, Shaun Harris, William Hollingworth et autres

Abstract The MAGENTA pragmatic parallel groups randomized controlled trial compared graded exercise therapy (GET) with activity management (AM) in treating paediatric myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS). Children aged 8-17 years with mild/moderate ME/CFS and presenting to NHS specialist paediatric services …

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Evaluating the Effectiveness of the SleepTracker App for Detecting Anxiety- and Depression-Related Sleep Disturbances

Doaa Alamoudi, Ian Nabney, Esther Crawley

This study emphasises the critical role of quality sleep in physical and mental well-being, exploring its impact on bodily recovery and cognitive function. Investigating poor sleep quality in approximately 40% of individuals with insomnia symptoms, the research delves into its potential diagnostic …

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EE238 Cost-Effectiveness of Online Cognitive Behavioral Therapy for Children with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) Compared to Online Activity Management: FITNET-NHS Trial Findings

Madeleine Cochrane, Ammar Annaw, Beverly A. Shirkey, Chris Metcalfe et autres

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Data Resource Profile: the Children and Young People with Long COVID (CLoCk) Study

Manjula D. Nugawela, Snehal M. Pinto Pereira, Natalia Rojas, Kelsey McOwat et autres

The Children and Young People with Long COVID (CLoCk) study is a national matched prospective study which was set up with the aims of (i) describing the clinical phenotype of post-COVID symptomology in children and young people (CYP), (ii) producing a research …

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"not one size fits all” The challenges of measuring paediatric health-related quality of life and the potential role of digital ecological momentary assessment: a qualitative study

Holly Fraser, Lauren Thompson, Esther Crawley, Matthew J Ridd et autres

PURPOSE: To explore the views of clinicians and researchers about the challenges of measuring health-related quality of life (HRQoL) in children (5-11 years) and to explore whether digital ecological momentary assessment (EMA) could enhance HRQoL measurement. METHODS: Semi-structured qualitative interviews with 18 …

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