Hung Pang Lee

Synthesis of hydrazine-functionalized Polyrotaxane and formation of adaptable sliding hydrogels

Sarah J. Loveland, Xinming Tong, Hung Pang Lee, Christine L. Zhou et autres

This work details the synthesis and characterization of Polyrotaxane-Hydrazine (PR-Hyd), a polyethylene glycol-based polymer utilized in the formation of Adaptable Sliding Hydrogels (ASG). ASG is a viscoelastic 3D cell culture system with reversible hydrazone bonds that can be leveraged to present cells …

us (code pays fourni par la source)

Adaptable sliding hydrogels enable pericellular pocket formation while enhancing MSC chondrogenesis and survival in 3D

Sarah J. Loveland, Xinming Tong, Manish Ayushman, Hung Pang Lee et autres

Hydrogels that recapitulate the dynamic mechanical cues of native extracellular matrix are powerful tools that can be leveraged for tissue engineering. Despite growing recognition that cues such as stress relaxation and plasticity modulate cell-matrix interactions, the influence of these properties on mesenchymal …

us (code pays fourni par la source)

Correction to “3D Printed Electronic Skin for Strain, Pressure and Temperature Sensing”

Shounak Roy, Kaivalya A. Deo, Hung Pang Lee, John Soukar et autres

Adv. Funct. Mater., 2024, 34, 2313575 DOI: 10.1002/adfm.202313575 Figure 1c contained an incorrect SEM image. A corrected image is provided here. This does not affect the results or conclusion of the study. We apologize for the oversight. Figure 1C.

Incorporating Bone‐Derived ECM into Macroporous Microribbon Scaffolds Accelerates Bone Regeneration

Cassandra Villicana, Ni Su, Andrew Z. Yang, Xinming Tong et autres

Tissue-derived extracellular matrix (tdECM) hydrogels serve as effective scaffolds for tissue regeneration by promoting a regenerative immune response. While most tdECM hydrogels are nanoporous and tailored for soft tissue, macroporosity is crucial for bone regeneration. Yet, there's a shortage of macroporous ECM-based …

us (code pays fourni par la source)

Tuning local matrix compliance accelerates mesenchymal stem cell chondrogenesis in 3D sliding hydrogels

Xinming Tong, Manish Ayushman, Hung Pang Lee, Fan Yang

us (code pays fourni par la source)

Sliding Hydrogels Reveal the Modulation of Mechanosensing Attenuates the Inflammatory Phenotype of Osteoarthritic Chondrocytes in 3D

Manish Ayushman, Hung Pang Lee, Pranay Agarwal, Georgios Mikos et autres

Osteoarthritis (OA) is a prevalen degenerative joint disease with no FDA-approved therapies that can halt or reverse its progression. Current treatments address symptoms like pain and inflammation, but not underlying disease mechanisms. OA progression is marked by increased inflammation and extracellular matrix …

us (code pays fourni par la source)

Cell tumbling enhances stem cell differentiation in hydrogels via nuclear mechanotransduction

Manish Ayushman, Georgios Mikos, Xinming Tong, Sauradeep Sinha et autres

us (code pays fourni par la source)

Granular Biphasic Colloidal Hydrogels for 3D Bioprinting (Adv. Healthcare Mater. 25/2024)

Kaivalya A. Deo, Aparna Murali, James J. Tronolone, Cole Mandrona et autres

Granular Colloidal Bioink A novel biphasic, granular colloidal bioink demonstrates outstanding rheological properties, print fidelity, and structural stability. It aids in engineering complex structures with multiple cell types and heterogeneous microenvironments. The biphasic ink consists of cell-laden hydrogel microparticles embedded in a …

Granular Biphasic Colloidal Hydrogels for 3D Bioprinting

Kaivalya A. Deo, Aparna Murali, James J. Tronolone, Cole Mandrona et autres

Granular hydrogels composed of hydrogel microparticles are promising candidates for 3D bioprinting due to their ability to protect encapsulated cells. However, to achieve high print fidelity, hydrogel microparticles need to jam to exhibit shear-thinning characteristics, which is crucial for 3D printing. Unfortunately, …

us (code pays fourni par la source)

3D Printed Electronic Skin for Strain, Pressure and Temperature Sensing (Adv. Funct. Mater. 22/2024)

Shounak Roy, Kaivalya A. Deo, Hung Pang Lee, John Soukar et autres

3D Printed Electronic Skin 3D-printed electronic skin, mimicking human sensitivity, advances wearable technology and human–machine interfaces. In article number 2313575, Akhilesh K. Gaharwar and co-workers show that its nanoengineering enables multifunctional capabilities, paving new paths in robotics and personal devices with motion, …

us, in (code pays fourni par la source)

3D Printed Electronic Skin for Strain, Pressure and Temperature Sensing

Shounak Roy, Kaivalya A. Deo, Hung Pang Lee, John Soukar et autres

Abstract Electronic skin (E‐skin) that can mimic the flexibility and stretchability of human skin with sensing capabilities, holds transformative potential in robotics, wearable technology, and healthcare. However, developing E‐skin poses significant challenges such as creating durable materials with skin‐like flexibility, integrating biosensing …

us, in (code pays fourni par la source)

Dynamically Cross-Linked Granular Hydrogels for 3D Printing and Therapeutic Delivery

Hung Pang Lee, Ryan Davis, Ting‐Ching Wang, Kaivalya A. Deo et autres

Granular hydrogels have recently emerged as promising biomaterials for tissue engineering and 3D-printing applications, addressing the limitations of bulk hydrogels while exhibiting desirable properties such as injectability and high porosity. However, their structural stability can be improved with post-injection interparticle cross-linking. In …

us (code pays fourni par la source)