ГИПЕРУРИКЕМИЯ У ПАЦИЕНТОВ С ВЫСОКИМ СОДЕРЖАНИЕМ ТРИГЛИЦЕРИДОВ. СОЧЕТАНИЕ ГЕНЕТИЧЕСКИХ, СРЕДОВЫХ ФАКТОРОВ И ТАКТИКА ЛЕЧЕНИЯ

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The increasing of uric acid level (hyperiricosuria) is regularly detected in blood during the examination of patient with such cardiovascular diseases as arterial hy-pertension, atherosclerosis, diabetes mellitus, metabolic syndrome and obesity. The hyperiricosuria and hypertriglyceridemia are two independent risk factors, espe-cially for arterial hypertension. The higher level of uric acid combined with hyper-lipoproteinemia (phenotypes) IIa andIIb was noted in 65% of patients. In males, hyperiricosuria was detected more often than in females. In groups with higher content of uric acid, the significant difference between median and quartiles was determined concerning the indicators of height, body mass, triglycerides concentra-tion, s-lipoprotein fractions content, pre s-lipoprotein fractions content, apolipo-protein E in blood serum and apolipoprotein B=100 lipoproteins, but not both apol-ipoprotein C=III and apolipoprotein E in lipoproteins of high density. The increase of concentration of triglycerides and uric acid in blood is the outcome of disorder of metabolism of fat acids and nucleotides under surplus intake of substances with food. The fructose of sweet drinks can be considered as the source of fructose. The fructose is capable to increase the concentration of uric acid. The catabolism of nucleotides is under regulatory impact of fructose: dicarboxylic derivatives can provoke increase of uric acid concentration. The treatment of patients with hyper-triglycerideimia, hyperiricosuria and hyperglycemia has to begin from decreasing of triglycerides concentration, dietotherapy and further, if it is necessary, to apply the hypolipidemic therapy with fibrates.

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