Accès ouvert déclaré 2026 article

Sentinel serosurvey for Mpox virus infection among key populations in India: Evidence of sporadic past exposure beyond travel-related cases

Megha Mamulwar, Sumit Aggarwal, Rima Rakeshkumar Sahay, Sonal Saxena, Hasina Banu, Swagnik Roy, S. Manjusree, Sudha Rani Vannavada, Kanwardeep Singh, Binoy Chandra R, Harikumar S.K., Aparna Banerjee, Kannan Mariyappan, A.K. Srikrishnan, Vijay Nair, Mohan Mahant, Prajakta Kadale, Anita Shete, Kuldeep Nigam, Neetu Vijay, Gayatri Bhambure, Rashmi G. Shinde, Rajlaxmi Jain, Pournami A.P., Shilpa Bembalkar, Raja Ray, Krishnaswamy Raj Hariandran, Megh Singh Dhakad, Athira R Nair, Srinath Mote, Deepak Mali, Ujjwala Gaikwad, Pragya Dhruv Yadav, Sheela Godbole, Nivedita Gupta

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Background and objectives Mpox, declared a public health emergency of international concern by WHO, has demonstrated sporadic transmission globally. While India reported 66 confirmed cases predominantly linked to international travel, the possibility of silent community circulation remains unconfirmed, particularly within high-risk populations. Serological surveys are crucial for detecting past exposure, including asymptomatic infections that may be missed by clinical surveillance. This study aimed to assess the prevalence of anti-MPXV IgG and IgM antibodies and identify socio-demographic and behavioural determinants of seropositivity among key populations in India. Methods A multicentric, cross-sectional sentinel serosurvey was conducted between September 2023 to March 2024 across seven community-based organisation sites in India. A total of 1,790 participants aged 18-40 y (born after cessation of smallpox vaccination in India) were enrolled. Serological testing was performed using enzyme-linked immunosorbent assay (ELISA) for anti-MPXV IgG and IgM antibodies. Plaque reduction neutralisation test (PRNT50) was used to assess functional neutralising antibodies against both MPXV and Vaccinia virus. Results Among 1,790 participants, 14 (0.78%) tested positive for anti-MPXV IgG, with no IgM positivity detected. IgG-positive individuals were predominantly male (57.1%), aged 31-40 y (85.7%), and sexually active (75.9%). Geographic distribution ranged from 0.34% (Delhi NCR) to 2.07% (Kerala). PRNT50 assay revealed functional neutralising antibodies against MPXV in 64.3% (9/14) of IgG-positive samples, with evidence of cross-reactive immunity to Vaccinia virus in 93.9% (13/14). Interpretation and conclusions This multicentric sentinel serosurvey identified very low Mpox virus seroprevalence (0.78%) among key populations in India, suggesting limited prior exposure. The absence of IgM antibodies indicates that infections were not recent and provides no evidence of ongoing community transmission during the study period. Detection of neutralising antibodies in a subset of IgG-positive individuals supports prior Orthopoxvirus exposure. These findings establish baseline sero-epidemiological evidence for Mpox in India and underscore the importance of periodic sentinel sero surveillance for early detection and outbreak preparedness.

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DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.

Titre Crossref: Sentinel serosurvey for Mpox virus infection among key populations in India: Evidence of sporadic past exposure beyond travel-related cases
Date Crossref: 19/09/2026
Éditeur: Scientific Scholar
Type: journal-article

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Où se fait cette recherche

National AIDS Research Institute pays non établi dans la notice
Structure de recherche
Indian Council of Medical Research pays non établi dans la notice
Organisme public
ICMR-National Institute of Virology Maximum Containment Facility pays non établi dans la notice
Structure de recherche
Maulana Azad Medical College Department of Microbiology pays non établi dans la notice
Université ou école supérieure
Institute of Post Graduate Medical Education and Research pays non établi dans la notice
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Government Medical College Department of Microbiology pays non établi dans la notice
Université ou école supérieure
Government of Kerala pays non établi dans la notice
Organisme public
Government Medical College and Hospital pays non établi dans la notice
Université ou école supérieure
Osmania Medical College Department of Microbiology pays non établi dans la notice
Établissement de santé
India HIV/AIDS Alliance pays non établi dans la notice
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Program for Appropriate Technology in Health pays non établi dans la notice
Organisation à but non lucratif
YR Gaitonde Centre for AIDS Research and Education pays non établi dans la notice
Organisation à but non lucratif

National AIDS Research Institute, Indian Council of Medical Research et Maximum Containment Facility — ICMR-National Institute of Virology, avec 9 autres affiliations.

Une affiliation ne permet pas de déduire la nationalité d’un auteur.

Les sujets associés

Poxvirus research and outbreaksBacillus and Francisella bacterial researchAutoimmune Neurological Disorders and Treatments

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