Complication Profile of Reoperative Thyroidectomy Versus First-Time Thyroidectomy: A Systematic Review and Meta-analysis
Rattachement africain : ie, cy, it, us, gb. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Introduction Reoperative thyroidectomy, defined as surgery for recurrent thyroid disease following prior thyroid resection, is widely perceived to carry a greater likelihood of complications than first-time thyroidectomy due to anatomic distortion and scar formation. Despite recognition of these challenges, the existing evidence is heterogeneous and lacks comprehensive synthesis. Thus, this meta-analysis aims to evaluate the comparative complication rates between reoperative and first-time thyroidectomy. Methods PubMed, Ovid Embase, Cochrane Library, CINAHL, Scopus, and Web of Science were searched from their respective inception dates to October 2025. The review was registered prospectively on the PROSPERO database (CRD420251158243). Results Twenty-three studies comprising 42,314 patients were included, of whom 4154 (9.8%) underwent reoperative thyroidectomy. Reoperative thyroidectomy was associated with greater odds of transient hypocalcemia (odds ratio [OR] = 1.53; 95% confidence interval [CI]: 1.06-2.20; I 2 = 84%), permanent hypocalcemia (OR = 1.88; 95% CI: 1.33-2.67; I 2 = 24%), transient recurrent laryngeal nerve (RLN) injury (OR = 2.57; 95% CI: 1.73-3.83; I 2 = 72%), permanent RLN injury (OR = 3.94; 95% CI: 2.60-5.97; I 2 = 47%), and hematoma (OR = 1.76; 95% CI: 1.12-2.78; I 2 = 7%) when compared with first-time thyroidectomy. Conclusions Reoperative thyroidectomy appears to carry a higher likelihood of complications than first-time thyroidectomy with an almost 4-fold increase in odds of permanent RLN injury. These findings emphasize the importance of appropriate patient counseling, careful patient selection, and clear clinical indications when considering reoperative thyroidectomy.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Complication Profile of Reoperative Thyroidectomy Versus First-Time Thyroidectomy: A Systematic Review and Meta-analysis
- Date Crossref
- 01/11/2026
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University College Dublin pays non établi dans la noticeUniversité ou école supérieure
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University of Nicosia pays non établi dans la noticeUniversité ou école supérieure
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University of Bari Aldo Moro pays non établi dans la noticeUniversité ou école supérieure
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Indiana University School of Medicine Department of Surgery pays non établi dans la noticeUniversité ou école supérieure
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Indiana University – Purdue University Indianapolis pays non établi dans la noticeUniversité ou école supérieure
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Cleveland Clinic Department of Endocrine Surgery pays non établi dans la noticeÉtablissement de santé
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Cambridge University Hospitals NHS Foundation Trust pays non établi dans la noticeOrganisme public
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Mayo Clinic Department of Surgery pays non établi dans la noticeÉtablissement de santé
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Cleveland Clinic Lerner College of Medicine pays non établi dans la noticeÉtablissement de santé
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Integrated Surgical Institute Department of Endocrine Surgery pays non établi dans la noticeStructure de recherche
University College Dublin, University of Nicosia et University of Bari Aldo Moro, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.