Pain Phenotypes in Patients with Inflammatory Myopathies: A Latent Class Analysis
Rattachement africain : us, jo. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: Pain is a common and burdensome symptom in patients with idiopathic inflammatory myopathies (IIM). Our aim was to identify pain phenotypes in IIM that may reflect distinct underlying mechanisms. METHODS: An anonymous electronic survey of patients with self-reported IIM and pain attributable to myositis was circulated. The survey included questions related to demographics, IIM-related information, pain characteristics and the Fibromyalgia Survey Questionnaire. Latent class analysis (LCA) was performed using four variables including distribution, pattern, difference in pain during myositis flare vs now, and disease duration. Class validity was assessed using pain characteristics, fibromyalgia criteria fulfilment and symptom burden. RESULTS: A total of 426 participants were included. LCA identified four classes: i) class 1 with proximal arm- and leg-predominant pain and lowest persistent pain, ii) class 2 with diffuse axial and proximal limb-predominant pain, iii) class 3 with diffuse axial and distal-leg predominant pain and iv) class 4 with widespread axial and extremity pain and the highest persistent pain. In post-hoc analyses, class 1 primarily included participants with earlier IIM and a lower rate of fibromyalgia. Class 2 and 3 included participants with intermediate fibromyalgia symptom burden while class 4 included participants with the highest pain intensity and fibromyalgia. CONCLUSION: In this large international cohort of patients with self-reported IIM and pain, we identified four different pain phenotypes. These phenotypes range from a localized disease-related nociceptive pattern to a widespread fibromyalgia-like nociplastic pattern. Our findings highlight the heterogeneity of myositis-related pain and may inform future mechanistic studies and phenotype-directed management strategies.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Pain Phenotypes in Patients with Inflammatory Myopathies: A Latent Class Analysis
- Date Crossref
- 15/09/2026
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Rush University Medical Center pays non établi dans la noticeÉtablissement de santé
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Jordan University of Science and Technology pays non établi dans la noticeUniversité ou école supérieure
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University of Illinois Chicago pays non établi dans la noticeUniversité ou école supérieure
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Northwestern University pays non établi dans la noticeUniversité ou école supérieure
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Northwestern Medical Faculty Foundation pays non établi dans la noticeOrganisation à but non lucratif
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University of Illinois at Chicago Chicago IL USA pays non établi dans la noticeUniversité ou école supérieure
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Myositis Support and Understanding Association Lincoln DE USA pays non établi dans la noticeOrganisation à but non lucratif
Rush University Medical Center, Jordan University of Science and Technology et University of Illinois Chicago, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.