Redox-Responsive Peptide Dimers to Stabilize and Release Therapeutic dsRNA

Le résumé fourni par la source

B1, B3, and C1 represent the strongest binders among a panel of 11 stapled peptides and effectively protect dsRNA from degradation [4] • ITC measurements show that 2′-2′ binds dsRNA with high affinity (K d = 31.7 nM), exhibiting a 10-fold stronger interaction than wt33 (K d = 328 nM)• Thermal denaturation experiments reveal increased melting temperatures for RNA-peptide complexes formed by 1′-1′ and 2′-2′ compared to their monomers • 2′-2′ binds dsRNA in a sequence-independent manner and extends the lifetime of miRNA-21 in FBS, preventing degradation for up to 6 hours in 27.5 % FBS at rt [5]

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.