Long-Term Follow-Up After Surgical Treatment of Anogenital and Oropharyngeal Condyloma Acuminata with Simultaneous HPV Vaccination Initiation in Patients with Concurrent HPV-16 or -18 Co-Infection
Rattachement africain : pl. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background/Objectives: Persistent infection with high-risk HPV genotypes accounts for the development of a substantial portion of anogenital and oropharyngeal malignancies. Patients with primary and secondary immunodeficiency or those receiving immunosuppressive therapy, including transplant recipients and patients affected by rare diseases, are vulnerable to particularly severe clinical manifestations of infection. While HPV vaccination constitutes primary prevention, patients with HPV-associated disease remain at risk of reinfection or subsequent infection with alternative genotypes following surgical treatment and may benefit from peri-operative vaccination regimens. This study aimed to evaluate long-term outcomes of HPV vaccination following surgical management of condyloma acuminata in patients with concurrent high-risk genotype infection. Methods: 350 patients with condyloma acuminata and HPV-16 or -18 co-infection confirmed by histopathological examination and PCR genotyping (oral cavity, vulva, vagina, penis, anoderma), including a subgroup with primary or acquired immunodeficiency or chronic immunosuppressive regimens, underwent surgical treatment, receiving simultaneous immunization with the first dose (subsequent completion of full regimen over 12 months) of the bivalent Cervarix vaccine (170 patients) or the quadrivalent Gardasil vaccine (180 patients). A follow-up examination, including HPV genotyping (16/18/31/35), was performed after 6 and 12 months following regimen completion. After 36 months, a standard clinical examination was performed, and in doubtful cases, supplemented with genotyping and biopsy/cytology. Observation was continued in subsequent years (5, 10, and >15 years). Results: Condyloma acuminata requiring removal were observed in 5% of the patients in follow-up at 36 months, with no significant statistical difference between vaccine groups. No cellular atypia or malignant transformation in the form of squamous cell carcinoma was observed. Genotyping did not detect HPV-16/18/31/35 infection in the follow-up examinations. Conclusions: In this uncontrolled, single-arm cohort, peri-operative initiation of either the bivalent or quadrivalent HPV vaccine was associated with a low rate of clinically apparent condyloma acuminata recurrence and no detectable HPV-16/18/31/35 infection during follow-up.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Long-Term Follow-Up After Surgical Treatment of Anogenital and Oropharyngeal Condyloma Acuminata with Simultaneous HPV Vaccination Initiation in Patients with Concurrent HPV-16 or -18 Co-Infection
- Date Crossref
- 10/09/2026
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Medical University of Warsaw Department of Biophysics pays non établi dans la noticeUniversité ou école supérieure
-
John Paul II Hospital pays non établi dans la noticeÉtablissement de santé
-
University of Siedlce Institute of Health Sciences pays non établi dans la noticeUniversité ou école supérieure
-
Medical University of Białystok pays non établi dans la noticeUniversité ou école supérieure
-
University of Warsaw pays non établi dans la noticeUniversité ou école supérieure
-
St. John Paul II Mazovian Regional Hospital in Siedlce Department of Obstetrics pays non établi dans la noticeÉtablissement de santé
-
Warsaw Medical Innovation Center JSC pays non établi dans la noticeInstitution
-
Faculty of Medical and Health Sciences pays non établi dans la noticeUniversité ou école supérieure
-
Medical University of Bialystok pays non établi dans la noticeUniversité ou école supérieure
-
VIZJA University pays non établi dans la noticeUniversité ou école supérieure
Department of Biophysics — Medical University of Warsaw, John Paul II Hospital et Institute of Health Sciences — University of Siedlce, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.