[Corrigendum] Antitumour activity of TH1579, a novel MTH1 inhibitor, against castration‑resistant prostate cancer

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TH1579 induces apoptosis in castration-resistant prostate cancer.(A) Representative images of flow cytometric analysis highlighting apoptosis in DU-145 and PC-3 cells treated with TH1579 for 72 h.(B) Flow cytometric quantification of apoptosis in PC-3 or DU-145 cells following PI and Annexin V staining.Values represent the mean ± SEM from three independent experiments.* P<0.01, each experiment group [including TH1579 (1.0 µM), TH1579 (0.5 µM) or Etoposide group vs. DMSO group]; Tukey's test.(C) Representative western blot images of cPaRP-1, p-p53 (S15) and γH2a.X expression levels from >3 independent experiments 24 h after incubation with TH1579.cPaRP-1, cleaved poly (aDP-ribose) polymerase 1; PI, propidium iodide..

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