A Carboxymethyl Chitosan/Tannic Acid@Ag Composite Hydrogel for Gastrointestinal Defect Sealing and Smart Motion Monitoring

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ABSTRACT Conductive hydrogels show great potential in flexible electronics and biomedical devices, yet their practical applications are often hindered by insufficient mechanical strength, poor environmental stability, and limited functionality. To address these challenges, this study has developed a hydrogel platform that integrates diagnosis and treatment, enabling real‐time monitoring and sealing of gastrointestinal defects. Through a well‐designed multi‐dynamic network, the hydrogel integrates tissue‐like stretchability (fracture strain up to 1420%), strong wet adhesion (adhesion strength 43 kPa), and broad‐spectrum antibacterial activity. Leveraging its unique hybrid ionic electronic conductive network, the material enables simultaneous capture of electrophysiological signals (ECG and EMG) and mechanical motions (intestinal peristalsis, cardiac contraction, and gastric activity), achieving multimodal physiological monitoring. Remarkably, while providing a continuous and stable signal sensing, the hydrogel effectively seals gastrointestinal defects, demonstrating excellent defect sealing capability. This work presents a hydrogel platform that breaks through the limitations of conventional single‐function materials, offering an innovative solution for closed‐loop intelligent diagnostic therapeutic systems, with significant potential in next‐generation bioelectronic medicine.

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