Real-world healthcare resource utilization and cost burden of COVID-19 in commercially insured adults at high-risk of severe disease in the US: a retrospective database analysis
Le résumé fourni par la source
High-risk patients with COVID-19 remained at elevated risk of severe outcomes in the Omicron era, even after receiving multiple vaccine doses. We report the Omicron-era healthcare resource utilization (HCRU) and cost burden of COVID-19 among commercially insured, oral antiviral therapy-eligible patients at high risk of severe disease. This retrospective analysis used the TriNetX Linked US database. Eligible commercially insured patients were aged ≥18 years, had a COVID-19 diagnosis between 1 July 2023 and 30 June 2024, and had ≥1 risk factor for severe COVID-19. All-cause and COVID-19-related HCRU and costs were assessed during acute (0–30 days from diagnosis) and post-acute (31 days until December 31, 2024) follow-up. Of the 43,487 eligible patients, 56.2% were aged ≥50 years and 85.6% had 1–5 high-risk conditions. Patients were followed for a mean of 11.4 months following COVID-19 diagnosis (acute phase, 1.0 month; post-acute phase, 10.6 months). 13,499 patients (31.0%) received treatment for COVID-19. 9.8% of patients had ≥1 all-cause inpatient general ward admission, with a mean per-patient (PP) total cost of $14,715 (acute phase, $10,833 PP; post-acute phase, $14,403 PP). 1.3% of patients had an all-cause intensive care unit (ICU) admission, with a mean PP total cost of $75,371 (acute phase, $62,882 PP; post-acute phase, $71,666 PP). Among the small number of patients requiring mechanical ventilation in the ICU, mean all-cause PP costs were $135,677 PP overall (acute phase, $106,577 PP; post-acute phase, $130,309 PP). 28.4% of patients had ≥1 all-cause emergency department visit (mean total cost, $1,434 PP; acute phase, $842 PP; post-acute phase, $1,408 PP). During the Omicron era, HCRU and costs remained substantial and increased with disease severity among commercially insured patients at high risk of severe COVID-19. These findings are crucial to inform economic evaluations and payer decision‑making regarding COVID‑19 antiviral therapies.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.