The Mulagua Study: A Spanish Cohort Renal on Renal Health - Protocol Description

Le résumé fourni par la source

Background: Chronic kidney disease (CKD) is a major public health problem, characterized by high cardiovascular morbidity and mortality with high healthcare costs. However, the actual prevalence of CKD in Spain is uncertain due to the wide variability of prevalence estimates (9%–15%) and the use of formulas based on creatinine or cystatin C, which have a random error margin of ±30%, limiting diagnostic reliability. This inaccuracy, together with the asymptomatic nature of CKD, leads to underdiagnosis of the disease and the resulting prevalence of occult kidney disease (O-CKD). Objectives: We designed the Mulagua Study, the first Spanish population-based cohort with measured Glomerular Filtration Rate (GFR). The main objective is to determine the actual prevalence of CKD using the measured mGFR based on plasma iohexol clearance using the dried blood spot (iohexol-DBS) technique. Secondary objectives include analyzing the error in estimation formulas, quantifying occult kidney disease, and evaluating the association of classic metabolic risk factors (metabolic syndrome, insulin resistance) with the disease. Methods: The study is population-based and cross-sectional in design, and will include 1,576 subjects aged ≥ 18 years from three municipalities in La Gomera, with a sample designed to reproduce the national population pyramid. In addition to mGFR, anthropometric and laboratory data will be collected, surveys of habits (diet, exercise, and socioeconomic status) will be conducted, and a serum, urine, and DNA biobank will be established, allowing prospective evaluation of CKD progression and its contributing factors in the future.

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