Retrospective single cell lineage tracing with highly mutable homopolymers

Résumé fourni par la source

Processed data for RETrace2: Retrospective single-cell lineage tracing with highly mutable homopolymers. This dataset contains processed single-cell microsatellite and methylation sequencing data generated using RETrace2, a dual-omic method for simultaneous lineage tracing and cell-type identification. RETrace2 uses homopolymer microsatellites as lineage markers, which are ~2x more informative than other repeat types, enabling lineage resolution of <5 cell divisions in microsatellite-unstable cells. Data includes microsatellite genotypes, phylogenetic trees, and associated quality metrics from in vitro cell line experiments and in vivo mouse models. Raw sequencing data is available at SRA (PRJNA1377203). v2 adds peer-review analyses in RETrace2_revision_analyses_v2.zip

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.