Abstract No: 019 ACETAZOLAMIDE-INDUCED PROXIMAL RENAL TUBULAR ACIDOSIS IN A TYPE 2 DIABETIC PATIENT

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Acetazolamide, a carbonic anhydrase inhibitor, is routinely employed in ophthalmic practice for the management of postoperative intraocular pressure elevation. While mild hyperchloremic metabolic acidosis is a recognized pharmacologic effect, severe symptomatic acidosis is rare. Patients with long-standing type 2 diabetes mellitus (T2DM) may have subclinical renal tubular dysfunction due to chronic hyperglycemia, rendering them particularly susceptible to drug-induced acid–base disturbances. Recognition of this potential drug–disease interaction is vital to prevent avoidable metabolic crises in diabetic individuals receiving acetazolamide therapy.