Nutraceutical administration targeting energy metabolism and antioxidant defences improves spermiogram and biochemical quality of seminal plasma of infertile males in a pilot study

Résumé fourni par la source

Pre- and post-intervention spermiogram analysis and high-performance liquid chromatography (HPLC) profiling of fat- and water-soluble seminal plasma (SP) metabolites were performed in 26 infertile men treated for 60 days with vitamin E + CoQ10 (intervention 1 on n = 6 participants with predominant fat-soluble compound alterations), vitamin E + CoQ10 + B-complex vitamins + vitamin C (intervention 2 on n = 12 participants with combined fat- and water-soluble compound alterations) and B-complex vitamins + vitamin C (intervention 3 on n = 8 participants with predominant water-soluble compound alterations). Intervention 1 improved only SP vitamin E levels, intervention 2 improved spermiogram, an index cumulating all metabolic SP alterations named biomarker score (BS) and fat- and water-soluble SP metabolites, intervention 3 improved spermiogram, BS and several water-soluble SP metabolites. In conclusion, personalised nutraceutical supplementations, administered on the basis of SP metabolic profile alterations, may improve semen quality of infertile males.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.