Methanolic leaf extract of Calotropis procera promotes early S100β upregulation and accelerates sensorimotor functional recovery in a mouse model of peripheral nerve injury

Résumé fourni par la source

Peripheral nerve injury (PNI) leads to significant loss of sensorimotor function and long-term disability, with limited options for complete recovery. In the current study, we investigated the neuroregenerative potential of Calotropis procera using a rodent model of sciatic nerve injury. A pharmacological screening approach was first employed to identify bioactive constituents and their predicted molecular targets. Based on these findings, a methanolic leaf extract of Calotropis procera leaves (CP-Ext) enriched in phenolic compounds was selected for further evaluation. Phytochemical analysis confirmed the presence of key constituents, including gallic acid, catechin, and quercetin. Functional assessment demonstrated that CP-Ext significantly improved recovery of sensory and motor function. In addition, treatment enhanced antioxidant defense mechanisms, as indicated by increased paraoxonase and arylesterase activities, and promoted early upregulation of the regeneration-associated protein S100β. These results indicate that CP-Ext facilitates nerve repair processes and supports its potential as a source for drug candidates for peripheral nerve regeneration.

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