Evaluation of the anti-inflammatory activity of aqueous and hydroethanolic extracts of the trunk bark of Harungana Madagascariensis (Hypericaceae) on carrageenan-induced acute rat paw edema

Résumé fourni par la source

The objective of this study was to evaluate the anti-inflammatory activity of aqueous (EAqHM) and hydroethanolic (EEtHM) extracts of the stem bark of Harungana madagascariensis in rats using carrageenan-induced paw edema. Groups of rats were treated with NaCl, diclofenac, or the respective plant extracts. The progression of edema was monitored over six hours, after which C-reactive protein (CRP) levels were determined. Both extracts significantly reduced edema in a dose-dependent manner. At 150 mg/kg, EAqHM exhibited the highest inhibitory activity, with an inhibition rate of 89.77% at the sixth hour, whereas EEtHM at 300 mg/kg achieved an inhibition rate of 82.90%. Treatment with EAqHM at 150 mg/kg also resulted in a significant reduction in C-reactive protein levels. These findings confirm the anti-inflammatory potential of H. madagascariensis and support its traditional use in the management of inflammatory conditions.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.