Supplementary Figures S1-S11 from Spatial Mapping of the Precancer-to-Cancer Transition in Breast and Prostate

Résumé fourni par la source

Supplementary Fig. 1. Lightsheet. Supplementary Fig. 2. 3D serial section workflow and motivation. Supplementary Figure 3. Serial section ROIs for HT206B1 (breast). Supplementary Fig. 4. Genes associated with 3D transition ROIs in breast and prostate. Supplementary Fig. 5. Serial section ROIs for HT913Z1 (prostate). Supplementary Fig. 6. 3D proximity of TAMs to non-invasive and invasive epithelial regions in HT704B1. Supplementary Fig. 7. Expression of cohort-level transition genes. Supplementary Fig. 8. Quantification and validation of transition markers. Supplementary Fig. 9. Wound healing assays for MGP and PLAT knockdowns in breast cancer cell lines. Supplementary Fig. 10. Wound healing assays for GDF15, FASN, ALDH1A3, and ANPEP knockdowns in PC-3 prostate cancer cell line. Supplementary Fig. 11. Expression for GDF15, ANPEP, ALDH3A1, and FASN in four prostate cancer cell lines, including PC-3.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.