Editorial: Beyond gastrointestinal symptoms: psychosocial implications of disorders of gut-brain interaction.

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relevant across the spectrum of gastrointestinal diseases, including conditions traditionally regarded as purely organic (1). The recent introduction of Rome V (2), consolidates this conceptual evolution by further moving the field away from the label "functional gastrointestinal disorders" and reinforcing the term DGBIs (3). This terminology better reflects current pathophysiological understanding, supports greater diagnostic precision, and provides a shared language grounded in a patient-centered biopsychosocial model (4).A growing body of evidence demonstrates that factors including sexual or gender minority status (5), adverse childhood experiences (6,7), chronic stress, anxiety, depression, neuroticism (8), maladaptive symptom-related cognitions such as hypervigilance and catastrophizing (9), influence not only symptom severity but also patients' daily lives.Reduced quality of life (QoL), lower happiness and life satisfaction, sexual dysfunction and urinary symptoms (10), disordered eating behaviors (11,12), presenteeism, absenteeism (13) and impaired social functioning are increasingly recognized as part of the clinical burden of digestive disorders. Understanding these conditions therefore requires moving beyond pathophysiology alone to consider the individual's lived experience (Figure 1).The studies presented in this research topic reflect this evolving vision of gastroenterology.Together, they span the life course and explore how biological, psychological, dietary, cultural, and sociocultural factors interact to shape digestive health. The narrative begins in early life with the investigation of umbilical cord biomarkers and their potential association with infantile colic and excessive crying. In an outstanding hypothesis article, Simonin et al.found that infants who later developed colic or excessive crying had higher trans fatty acid levels and a greater Gammaproteobacteria signature in cord blood at birth. This innovative study suggests that perinatal metabolic and microbial factors may contribute to the early Rather than presenting digestive disorders as isolated entities, these studies collectively portray gastrointestinal health as the product of interconnected biological, psychological, behavioral, dietary, autonomic, cultural, and social influences. In doing so, they reflect the continuing evolution of gastroenterology towards a truly person-centered discipline, in which understanding the gut also requires understanding the brain, the environment, the mind and the lived experience of the individual.The shift toward precision medicine and multimodal assessment is challenging traditional diagnostic approaches. DGBIs are complex because physiological changes and individual experiences interact to shape symptoms and disease burden. Cluster analyses have identified distinct patient profiles based on gastrointestinal and extraintestinal symptoms, psychological burden, lifestyle, and biological factors (14)(15)(16)(17)(18)(19). Microbiome and multi-omics analyses may further refine these profiles and help explain why patients with the same Rome V diagnosis can have different symptoms and treatment responses. Although these tools are not yet ready for routine clinical use, they may support more personalized care in the future. Moreover, new hypotheses suggest that modern life may cause "sensory malnutrition" by reducing diverse body stimuli, disrupting body-brain communication and contributing to anxiety, somatic hypervigilance, visceral hypersensitivity and DGBIs, offering new perspectives for future research (20).As our understanding of digestive diseases moves beyond gastrointestinal symptoms alone, integrating biological and psychosocial mechanisms will be essential to explain clinical heterogeneity and advance precision medicine. Combining multi-omics approaches, artificial intelligence, microbiota analysis, and comprehensive clinical and psychological phenotyping may enable a deeper understanding of disease mechanisms and support more accurate prediction, prevention, and personalized management of DGBIs.