Study of the combined effect of CTAB functionalized gold nanorods and radiation on tumor cell metabolism via MRS technique

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Abstract Gold nanorods (AuNRs) are promising nanomaterials for theragnostic applications due to their unique optical and physicochemical properties, making them suitable for biomedical imaging and drug delivery. The presence of a radiopharmaceutical bound to AuNRs may induce Auger electron emission during radioactive decay, enhancing localized energy deposition and therapeutic effects. In this study, CTAB-stabilized AuNRs were synthesized and characterized. AuNRs impact on the metabolism of a glioblastoma cell line (T98G) was investigated in combination with ionizing radiation (20 Gy, Cs-137). A non-invasive Magnetic Resonance Spectroscopy (MRS) approach was used to analyze intact cells at different time points after treatment. 1 H 1D and 2D COSY spectra acquired at 600 MHz revealed variations in glutathione (GSH) and mobile lipid (ML) signals, associated with oxidative stress response and cell viability. Preliminary results suggest a potential synergistic effect between AuNRs and ionizing radiation.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.