Perioperative invasiveness of endoscopic tumor biopsy for primary central nervous system lymphoma: comparison with stereotactic tumor biopsy

Résumé fourni par la source

Background In patients with primary central nervous system lymphoma (PCNSL), surgical intervention is limited to biopsy for pathological diagnosis. Stereotactic tumor biopsy (STB) is widely used due to minimal invasiveness. However, blind sampling carries a hemorrhage risk and may yield insufficient tissue. Endoscopic tumor biopsy (ETB) has emerged to address these limitations, yet its perioperative invasiveness relative to other biopsy techniques remains inadequately characterized. Objective This study aimed to evaluate the perioperative invasiveness and feasibility of ETB compared with STB in patients with PCNSL. Methods We retrospectively reviewed 28 consecutive patients with PCNSL who underwent tumor biopsy: open tumor biopsy (OTB; n = 12), STB ( n = 7), and ETB ( n = 9). Operative variables, including bone-opening size, operative time, and blood loss, were analyzed along with perioperative inflammatory response measured by C-reactive protein (CRP). Results The three groups did not differ significantly in age, preoperative Karnofsky performance status, tumor size, operative time, or blood loss. Tumors approached via OTB were closer to the brain surface and required significantly larger bone-opening sizes than those approached via STB or ETB. Perioperative CRP elevation was greater in the OTB group. No statistically significant differences in the measured perioperative parameters were detected between the STB and ETB groups. No surgery-related complications occurred in any patient. Conclusions ETB may be a minimally invasive procedure and could be one of the options for biopsy of PCNSL.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.