Inflammation and neuropsychiatric symptoms in Parkinson's disease: a genetic association

Résumé fourni par la source

Background There has been some evidence that neuroinflammation is involved in Parkinson's disease (PD) and in psychiatric disorders. Objective To explore the effects of IL-1β rs16944 on PD patients' neuropsychiatric symptoms. Methods Two hundred and eighty-one consecutive PD patients underwent a neurological and neuropsychological evaluations, which included: Unified Parkinson's Disease Rating Scale, Schwab and England Activities of Daily Living scale, Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease—Anytime Short, Hospital Anxiety and Depression Scale and Dementia Rating Scale-2. The Neuropsychiatric Inventory (NPI) was also applied to patients' caregivers/informants. In addition to IL-1β rs16944, DRD3 rs6280 and GRIN2B rs7301328 were also genotyped. Non-parametric group comparisons and linear and logistic regressions were used for data analyses. Results The IL-1β rs16944 (specifically TT vs. CC) genotype was associated with increased frequency of impulse-control behaviors and disorders (ICBDs) and impulse control disorders (ICDs; OR = 3.54, p = 0.004 and OR = 3.63, p = 0.006, respectively) and with more NPI reports of hallucinations (OR = 3.92, p = 0.014) and more neuropsychiatric symptoms (ß = 0.73, p = 0.019). The rs16944 T allele was related to more NPI reports of hallucinations (OR = 2.31, p = 0.032) and agitation/aggression (OR = 2.02, p = 0.039). Conclusion Study findings suggest that a polymorphism previously associated with increased IL-1β expression may increase the risk of certain neuropsychiatric symptoms in PD.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.