Accès ouvert déclaré 2026 article

Predictors of complete obliteration and favourable outcome after single-modality treatment for low-grade arteriovenous malformations: a multicentre study

Angelica M. Fuentes, Salem M Tos, Natasha Ironside, Georgios Mantziaris, Yuki Shinya, Basel Musmar, Hamza Salim, Nimer Adeeb, Christopher S Ogilvy, Douglas Kondziolka, Ali Alaraj, Min S. Park, Adam A. Dmytriw, Hussein Zeineddine, F. McCarthy, Hussam Abou-Al-Shaar, Ahmed Abdelsalam, Mustafa Baskaya, Cagdas Ataoglu, Anthony Sanchez‐Forteza, Muhammed Amir Essibayi, Abdullah Keleş, Sandeep Muram, Howard Riina, Arwin Rezai, Şahin Hanalıoğlu, Ufuk Erginoğlu, Johannes Pöppe, Davide Simonato, Yan-Lin Li, Sandeep Kandregula, Dhairya A. Lakhani, Christoph J Griessenauer, Rahim Abo Kasem, Alejandro M Spiotta, Ajit S Puri, Jasmeet Singh, Anna Luisa Kuhn, Jan‐Karl Burkhardt, Robert M Starke, Laligam N. Sekhar, Michael R. Levitt, David Altschul, Neil Haranhalli, Malia McAvoy, P. Foreman, Osama O. Zaidat, M. AlMajali, Hakeem J Shakir, Alfred P. See, Adib A. Abla, Aashay Patel, Andrew Nguyen, Matthew J. Koch, Visish M. Srinivasan, Peng Roc Chen, Spiros Blackburn, Ketan R. Bulsara, Peter Kan, Louis Kim, Omar Choudhri, Stavropoula I Tjoumakaris, Pascal Jabbour, Amey Savardekar, Hugo H Cuellar, Michael T. Lawton, Bharat Guthikonda, Jacques Morcos, Jason P. Sheehan

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Le résumé fourni par la source

INTRODUCTION: Patient and arteriovenous malformation (AVM) characteristics that portend success after treatment for low-grade brain AVMs remain unknown. PATIENTS AND METHODS: We utilised the MISTA multicentre registry to identify patients with Spetzler-Martin (SM) grade I or II AVMs treated with stand-alone curative-intent intervention (resection, stereotactic radiosurgery [SRS] or endovascular embolisation). Bivariate and multivariable analyses were performed to identify patient and AVM characteristics predictive of complete obliteration or favourable outcome (complete obliteration without new permanent deficit or post-treatment haemorrhage). RESULTS: A total of 522 patients were included (292 microsurgery, 152 SRS, 78 embolisation). Complete obliteration rates differed between microsurgery (95.9%), SRS (75.0%) and embolisation (71.8%) (P < .001); among patients classified as cured, digital subtraction angiography (DSA) confirmed obliteration in 96.1%, 75.9% and 52.4%, respectively. Favourable outcome was achieved in 89.4%, 64.5% and 67.9% (P < .001). In adjusted models for obliteration, elderly age (odds ratio [OR] 0.49, P = .022), larger nidus (OR 0.64, P = .005) and compacted morphology (OR 1.93, P = .019) were independent predictors overall; paediatric age predicted incomplete obliteration after microsurgery (OR 0.05, P = .045), and elderly age (OR 0.19, P = .001) and larger nidus (OR 0.59, P = .015) after SRS. For favourable outcome, SM grade II overall (adjusted OR [aOR] 0.58, P = .031) and elderly age after SRS (aOR 0.31, P = .019) were independent negative predictors. DISCUSSION: Low-grade AVMs showed high rates of complete obliteration, though DSA-confirmed rates were substantially lower after embolisation, underscoring the importance of angiographic confirmation. CONCLUSION: The predictors identified in this study may help guide management when 2 or 3 of the primary treatment options carry clinical equipoise.

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DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.

Titre Crossref: Predictors of complete obliteration and favourable outcome after single-modality treatment for low-grade arteriovenous malformations: a multicentre study
Date Crossref: 01/08/2026
Éditeur: Oxford University Press (OUP)
Type: journal-article

Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.

Les institutions déclarées

University of Virginia Thomas Jefferson University Hospital Louisiana State University The University of Texas MD Anderson Cancer Center University Medical Center New Orleans Louisiana State University Health Sciences Center New Orleans Harvard University Boston Symphony Orchestra New York University University of Illinois Chicago University of Chicago Loyola University Chicago Brigham and Women's Hospital Bioanalytica (Switzerland)The University of Texas Health Science Center University of Miami University of Wisconsin–Madison Albert Einstein College of Medicine Montefiore Medical Center Christian Doppler Klinik Oxford University Hospitals NHS Trust University of Pennsylvania West Virginia University Blanchette Rockefeller Neurosciences Institute Medical University of South Carolina University of Massachusetts Chan Medical School University of Washington Orlando Health St. Vincent's Medical Center University of Oklahoma Health Sciences Center Boston Children's Hospital Boston Children's Museum University of Florida Mansfield University University of Connecticut The University of Texas Medical Branch at Galveston Barrow Neurological Institute

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Les sujets associés

Vascular Malformations Diagnosis and TreatmentVascular Anomalies and TreatmentsIntracranial Aneurysms: Treatment and Complications

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