Retinal microvascular lesions and the risk of stroke after subarachnoid hemorrhage

Résumé fourni par la source

Objective Delayed cerebral ischemia (DCI) is a fatal complication of subarachnoid hemorrhage (SAH) causing high mortality and disability. This study aimed to explore the predictive value of optical coherence tomography angiography (OCTA)-based retinal macular microvascular density for SAH-related cerebral vasospasm and infarction. Methods Sixty enrolled subjects were divided into SAH with cerebral infarction, pure SAH and healthy control groups (20 cases each). Macular superficial and deep capillary plexus densities in four subregions (C1–C4) were analyzed. One-way ANOVA with post-hoc pairwise t -test was used for statistical analysis, and ROC curves were applied to evaluate predictive efficacy. Results The SAH-infarction group showed significantly reduced vascular density in C1 and C2 subregions ( p < 0.05), while C3 and C4 density showed no significant changes. C1 and C2 vessel density exhibited good predictive performance, with superficial AUCs of 0.85, 0.743 and deep AUCs of 0.80, 0.69. Conclusion Regional retinal microvascular reduction is characteristic of SAH patients with secondary cerebral infarction. OCTA parameters have promising clinical value for early screening and prognosis assessment of post-SAH DCI.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.