Longitudinal association between body mass index-adjusted skeletal muscle mass and domain-specific progression of locomotive syndrome in community-dwelling adults aged 50 years and older

Le résumé fourni par la source

Locomotive syndrome (LS) is characterized by mobility decline in older adults and is associated with future long-term care needs and reduced independence. Skeletal muscle mass plays a crucial role in maintaining mobility. However, the longitudinal association between appendicular skeletal muscle mass adjusted for body mass index (ASM/BMI) and LS progression remains insufficiently examined. This study examined the association between baseline ASM/BMI and LS progression by each LS assessment component. This prospective cohort study followed community-dwelling adults aged ≥50 years for 1 year. LS progression was evaluated using changes in the two-step test, stand-up test, and the 25-question geriatric locomotive function scale (GLFS-25). ASM was assessed using bioelectrical impedance analysis, and ASM/BMI was calculated as ASM divided by body mass index. Associations were examined using multivariable logistic regression models adjusting for age, sex, and baseline LS stage. Incidence of LS progression differed across components. Higher baseline ASM/BMI was significantly associated with a lower risk of LS progression assessed by the two-step test (adjusted odds ratio per 0.01-unit increase, 0.94; 95% confidence interval, 0.90–0.98). Baseline ASM/BMI was not significantly associated with LS progression based on the stand-up test or GLFS-25. Among community-dwelling adults aged ≥50 years, lower baseline ASM/BMI was associated with a higher likelihood of LS progression in dynamic mobility capacity assessed by the two-step test, but not with overall LS progression based on the stand-up test or GLFS-25. These results suggest that ASM/BMI is a domain-specific predictor for declines in walking-related mobility.

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